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The Relationship Between Body Mass Index and Bone Mineral Density: A Mendelian Randomization Study
Calcified Tissue International ( IF 4.2 ) Pub Date : 2020-09-28 , DOI: 10.1007/s00223-020-00736-w
Jidong Song 1 , Rupeng Zhang 1 , Leifeng Lv 1 , Jialin Liang 1 , Wei Wang 1 , Ruiyu Liu 1 , Xiaoqian Dang 1
Affiliation  

Body mass index (BMI) is closely associated with bone mineral density (BMD) in both men and women. However, the relationship between BMI and BMD varies according to different studies. Using SNPs strongly associated with BMI in 336,107 individuals, we conducted a two-sample Mendelian randomization study to identify whether and to what extent BMD at different skeletal sites was affected by BMI. A power calculation was also performed. We found that BMI may causally increase lumbar BMD (β 0.087; 95% CI 0.025 to 0.149; P = 0.006) and heel calcaneus BMD (β 0.120; 95% CI 0.082 to 0.157; P = 1 × 10–7). The associations of BMI with forearm and femoral neck BMD were not statistically significant. Our study suggested that higher BMI plays a causal role in increasing BMD and the effects are similar across the skeleton. BMI was causally and positively associated with lumbar and heel calcaneus BMD. However, no statistically significant effects were observed for BMI on femoral neck or forearm BMD.



中文翻译:

体重指数与骨矿物质密度的关系:孟德尔随机研究

男性和女性的体重指数(BMI)与骨矿物质密度(BMD)密切相关。但是,根据不同的研究,BMI和BMD之间的关系有所不同。我们使用336107名个体中与BMI密切相关的SNP,进行了两次样本的孟德尔随机研究,以确定不同骨骼部位的BMD是否受BMI影响以及在多大程度上受BMI影响。还进行了功率计算。我们发现,可以BMI因果增加腰椎骨密度(β 0.087; 95%CI为0.025〜0.149; P  = 0.006)和脚跟跟骨BMD(β 0.120; 95%CI 0.082到0.157; P  = 1×10 -7)。BMI与前臂和股骨颈BMD的相关性无统计学意义。我们的研究表明,较高的BMI在增加BMD中起因果作用,并且整个骨骼的影响相似。BMI与腰跟跟骨BMD成因且正相关。但是,没有观察到BMI对股骨颈或前臂BMD有统计学意义的影响。

更新日期:2020-09-28
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