Most drugs are designed for immediate release via oral administration, releasing the dosage rapidly. Those administration forms can present a wide variation in drug concentrations, which can be harmful to a patient, when the amount of drug is either below or above the therapeutic range. Modified‐release formulations promise to alleviate the problems inherent to immediate‐release drugs by modifying their form of encapsulation. A sericin/alginate blend was applied as a matrix to modify the release of furosemide. The influence of furosemide and alginate concentration was evaluated in the incorporation efficiency and release time of 85% of drug content using a 2² full‐factorial experimental design. Various analytical techniques were employed to characterize the produced drug particles.

中文翻译：

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通过使用实验设计方法将呋塞米掺入丝胶和藻酸盐基质中来开发改良的药物递送系统

大多数药物被设计为通过口服立即释放，从而迅速释放剂量。当药物的量低于或高于治疗范围时，那些给药形式可表现出很大的药物浓度变化，这可能对患者有害。缓释制剂有望通过改变其封装形式来缓解速释药物固有的问题。将丝胶蛋白/藻酸盐混合物用作基质以改变速尿的释放。使用2 ²全因子实验设计评估了呋塞米和藻酸盐浓度对掺入效率和药物含量的85％释放时间的影响。采用了多种分析技术来表征所产生的药物颗粒。