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Development of a polarization imaging method to detect paraffin‐embedded pathology tissues before applying other techniques
Journal of Biophotonics ( IF 2.8 ) Pub Date : 2020-09-27 , DOI: 10.1002/jbio.202000288
Ouafa Sijilmassi 1, 2 , José Manuel López-Alonso 2 , Aurora Del Río Sevilla 1 , María Del Carmen Barrio Asensio 1
Affiliation  

The present article describes the development of a technique, applied to paraffin‐embedded tissues, which uses three different wavelengths of monochromatic light (λ1 = 445 nm, λ2 = 540 nm and λ3 = 660 nm) for the measures of the degree of polarization, degree of linear polarization, degree of circular polarization and birefringence, all obtained from measurements of Stokes parameters by using polarized light. The goal of this study was to detect changes in developing embryonic mouse eye when pregnant mice fed diets without folic acid for variable periods compared with a healthy control group. We present a biomedical diagnostic technique based on polarized light detection applied to paraffin‐embedded tissues to visualize the structural damage to aid us in the diagnosis before applying other techniques. Through this method, we can visualize and identify which parts of the tissue were altered with respect to the control group.image

中文翻译:

开发极化成像方法以在应用其他技术之前检测石蜡包埋的病理组织

本文介绍了应用于石蜡包埋组织的技术的发展,该技术使用三种不同波长的单色光(λ1= 445 nm,λ2= 540 nm和λ3= 660 nm)来测量偏振度,线性偏振度,圆偏振度和双折射都可以通过使用偏振光测量斯托克斯参数来获得。这项研究的目的是,与健康对照组相比,当怀孕的小鼠在不同的时间段内饲喂不含叶酸的饮食时,可以检测发育中的胚胎小鼠眼的变化。我们提出了一种基于偏振光检测的生物医学诊断技术,该技术应用于石蜡包埋的组织,以可视化结构损伤,以帮助我们在应用其他技术之前进行诊断。通过这种方法,图片
更新日期:2020-09-27
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