The aim of this study was to investigate the appearance of a disturbed oropharyngeal microbiota during hospitalization and explore the patient characteristics that maybe associated with such a disturbance. Oropharyngeal swabs were collected from 134 patients at hospital admission and every 3–4 days thereafter. The samples were cultivated to determine the presence of a disturbed microbiota, which, in turn, was subcategorized into respiratory tract pathogens, gut microbiota and yeast species. Demographics, medical history data and hospitalization events were compared. The percentage of disturbed oropharyngeal microbiota increased significantly with length of stay (LOS). Receiving antibiotic treatment during the hospitalization tended to be associated with a disturbed microbiota (OR 2.75 [0.99–7.60]). Proton pump inhibitor (PPI) medication and receiving antibiotics before hospitalization were associated with the development of a disturbed oropharyngeal microbiota with colonization of gut pathogens (OR 3.49 [1.19–10.2] and OR 4.52 [1.13–18.1], respectively), while acute hospital admission was associated with a lower risk of colonization of gut pathogens (OR: 0.23 [0.074–0.72]). The risk of developing a disturbed oropharyngeal microbiota increased with LOS in hospitalized patients. PPI medication and receiving antibiotics before hospitalization were independent risk factors for developing oropharyngeal colonization of gut pathogens.

中文翻译：

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与抗生素和质子泵抑制剂药物及住院时间有关的口咽微生物群紊乱

这项研究的目的是调查住院期间口咽部微生物菌群的出现，并探讨可能与这种疾病有关的患者特征。入院时及其后每3-4天从134例患者中收集口咽拭子。培养样品以确定是否存在受干扰的微生物群，然后将其细分为呼吸道病原体，肠道微生物群和酵母菌种。比较了人口统计学，病史数据和住院事件。口咽微生物群受到干扰的百分比随住院时间（LOS）的增加而显着增加。住院期间接受抗生素治疗往往与微生物群紊乱有关（OR 2.75 [0.99–7.60]）。质子泵抑制剂（PPI）的药物治疗和住院前接受抗生素的治疗与口咽微生物群的形成和肠道病原体的定殖有关（分别为OR 3.49 [1.19-10.2]和OR 4.52 [1.13-18.1]），而在急诊医院入院与肠道病原体定植的风险较低相关（OR：0.23 [0.074–0.72]）。住院患者因LOS而发生口咽微生物群紊乱的风险增加。PPI药物治疗和住院前接受抗生素是发展肠道病原体口咽定植的独立危险因素。而急性入院与肠道病原菌定植的风险较低相关（OR：0.23 [0.074–0.72]）。住院患者因LOS而发生口咽微生物群紊乱的风险增加。PPI药物治疗和住院前接受抗生素是发展肠道病原体口咽定植的独立危险因素。而急性入院与肠道病原菌定植的风险较低相关（OR：0.23 [0.074–0.72]）。住院患者因LOS而发生口咽微生物群紊乱的风险增加。PPI药物治疗和住院前接受抗生素是发展肠道病原体口咽定植的独立危险因素。