Knowledge on charge-transfer complexes of drugs is important to understand the drug-receptor binding mechanism. Here, we have been synthesized the organic charge transfer complex of Benzimidazolium picrate (BP) and confirmed its molecular structure and carbon skeleton by 1H and 13C NMR spectral analysis. Asymmetric unit of BP consists of one benzimidazolium cation and a monovalent anion of picric acid. Decomposition pattern and thermal stability BP have been investigated using TG/DTA analysis. The interaction of the compound with calf thymus DNA is investigated by electronic absorption spectroscopy which indicates that the compound could interact with DNA through intercalation. The CT complex demonstrated significant free radical scavenging with 2,2-diphenyl-2-picryl-hydrazyl. The BP complex has been also screened for its antimicrobial activity.

中文翻译：

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苯并咪唑鎓苦味酸盐单晶：合成，生长，表征及其生物学活性

关于药物的电荷转移复合物的知识对于理解药物受体结合机制很重要。在这里，我们已经合成了苯并咪唑鎓苦味酸盐（BP）的有机电荷转移配合物，并通过1H和13C NMR光谱分析证实了其分子结构和碳骨架。BP的不对称单元由一个苯并咪唑鎓阳离子和一价苦味酸阴离子组成。已经使用TG / DTA分析研究了分解模式和热稳定性BP。通过电子吸收光谱法研究了该化合物与小牛胸腺DNA的相互作用，这表明该化合物可以通过嵌入与DNA相互作用。CT复合物显示出明显的2,2-二苯基-2-吡啶基-肼基清除自由基的能力。BP复合物也已筛选出其抗菌活性。