In situ incorporating versatile magnetic iron nanoparticles into ordered mesoporous carbon (OMC) by means of synthetic methodology for functional integration is a great challenge. Inspired by the phenomenon of uniovular twins in nature, a homometallic [Fe₉(μ₃-O)₄(O₃PPh)₃(O₂CCMe₃)₁₃] ({Fe₉P₃}) cluster was synthesized and used as the ovulum to in situ produce dual-Fe nanoparticle (γ-Fe₂O₃ and Fe(PO₃)₃)-functionalized OMC (dual-Fe/OMC). In vitro magnetic resonance imaging (MRI) studies showed a longitudinal relaxation (r₁) and transverse relaxation (r₂) of 9.74 and 26.59 mM⁻¹ s⁻¹ with a r₂/r₁ ratio of 2.73 at 0.5 T. The MRI performances were further examined by mouse model with a subcutaneous HeLa tumor. In addition, the low cytotoxicity, considerable loading capacity and delivery of doxorubicin hydrochloride (DOX) were also studied in vitro. These results demonstrate the feasibility of the concept of uniovular twins in the one-pot preparation of dual-Fe/OMC for functional integration.

中文翻译：

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将双铁纳米粒子原位嵌入同步生成的碳中，实现磁共振成像和药物输送的协同整合

通过功能整合的合成方法将多功能磁性铁纳米颗粒原位结合到有序介孔碳（OMC）中是一个巨大的挑战。受自然界中单卵双胞胎现象的启发，合成了同金属[Fe ₉ (μ ₃ -O) ₄ (O ₃ PPh) ₃ (O ₂ CCMe ₃ ) ₁₃ ] ({Fe ₉ P ₃ })簇作为胚珠原位产生双Fe纳米颗粒(γ-Fe ₂ O ₃和Fe(PO ₃ ) ₃ )-功能化的OMC(dual-Fe/OMC)。体外磁共振成像 (MRI) 研究显示，纵向弛豫 ( r ₁ ) 和横向弛豫 ( r ₂ ) 分别为 9.74 和 26.59 mM ^-1 s ^-1，在 0.5 T 时r ₂ / r ₁比率为 2.73。通过具有皮下HeLa肿瘤的小鼠模型进一步检查了性能。此外，还在体外研究了盐酸多柔比星 (DOX) 的低细胞毒性、可观的负载能力和递送。这些结果证明了单卵双胞胎概念在双Fe/OMC的一锅制备中用于功能整合的可行性。