Application of low intensity electric fields to interfere with tumor growth is being increasingly recognized as a promising new cancer treatment modality. Intratumoral modulation therapy (IMT) is a developing technology that uses multiple electrodes implanted within or adjacent tumor regions to deliver electric fields to treat cancer. In this study, the determination of optimal IMT parameters was cast as a mathematical optimization problem, and electrode configurations, programming, optimization, and maximum treatable tumor size were evaluated in the simplest and easiest to understand spherical tumor model. The establishment of electrode placement and programming rules to maximize electric field tumor coverage designed specifically for IMT is the first step in developing an effective IMT treatment planning system.

中文翻译：

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在肿瘤内调制治疗中优化多电极植入物配置和编程，以提供非消融电场

低强度电场的应用，以干扰肿瘤的生长已被越来越多地认为是一种有希望的新的癌症治疗方法。肿瘤内调制疗法（IMT）是一项发展中的技术，它使用植入在肿瘤区域内或附近的多个电极来输送电场来治疗癌症。在这项研究中，确定最佳IMT参数被视为一个数学优化问题，并且在最简单，最容易理解的球形肿瘤模型中评估了电极配置，编程，优化和最大可治疗肿瘤大小。建立电极放置和编程规则以最大化专为IMT设计的电场肿瘤覆盖范围是开发有效的IMT治疗计划系统的第一步。