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Phosphorylation and acylation transfer reactions: Clues to a dual origin of metabolism
Biosystems ( IF 1.6 ) Pub Date : 2020-09-26 , DOI: 10.1016/j.biosystems.2020.104260
Miguel Ángel Freire 1
Affiliation  

Many theories of the origin of life focus on only one primitive polymer as an archetype of a world paradigm. However, life would have emerged within more complex scenarios where a variety of molecules and diverse polymers interconnected by a few similar chemical reactions. Previous work suggested that the ancestors of all major biopolymers would have arisen from abiotic template independent replication processes. They would have been organized in two closed sets of polymerization cycles: polysaccharides, polyribonucleotides and polyphosphates on one site; and peptides, fatty acids and polyhydroxyalkanoates on the other site. Then, these polymerization reaction cycles integrated into a minimal organization closure. Here, the purpose was to explore which kind of reactions could have supported the chemical networks that led to the early (bio)polymers. As a result, the proposed overview suggests that phosphorylation and acylation transfer reactions would have arisen independently and forged two distinct chemical systems that provided the phosphorylated and carboxylated intermediates used for the synthesis of the corresponding polymers. In this sense, modern metabolism may still reflect its dual nature, probably relying on these two reaction networks from the beginnings.



中文翻译:

磷酸化和酰化转移反应:代谢双重起源的线索

许多关于生命起源的理论只关注一种原始聚合物作为世界范式的原型。然而,生命会出现在更复杂的场景中,在这些场景中,各种分子和不同的聚合物通过一些类似的化学反应相互连接。以前的工作表明,所有主要生物聚合物的祖先都来自非生物模板独立复制过程。它们将被组织成两组封闭的聚合循环:一个位点上的多糖、多核糖核苷酸和多磷酸盐;和肽、脂肪酸和聚羟基链烷酸酯在另一个位点。然后,这些聚合反应循环整合到最小的组织闭合中。在这里,目的是探索哪种反应可以支持导致早期(生物)聚合物的化学网络。因此,拟议的概述表明磷酸化和酰化转移反应将独立发生并形成两个不同的化学系统,提供用于合成相应聚合物的磷酸化和羧化中间体。从这个意义上说,现代新陈代谢可能仍然反映了它的双重性质,很可能从一开始就依赖于这两个反应网络。

更新日期:2020-10-02
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