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Protective response of Sestrin under stressful conditions in aging
Ageing Research Reviews ( IF 13.1 ) Pub Date : 2020-09-26 , DOI: 10.1016/j.arr.2020.101186
Nitish Rai , Sharmistha Dey

The aging at cellular level manifests itself in the form of uncontrolled formation of ROS, chronic inflammation, and increased susceptibility to cellular stress. Aging is often regarded as a risk factor for several diseases due to several age-associated pathological changes in cells. Sestrin (Sesn) is an important molecule for controlling normal cellular physiology and play a significant role in the progression of certain age-associated cellular pathologies. This review deals with the structure, function, regulation, signaling network, and the potential role of Sesn in age-associated cellular pathophysiology. The cellular response mediated by Sesn under stressful conditions and rescue mechanism is discussed. It would be interesting to find out the precise physiological role of Sesn in the regulation of cellular aging. The anti-aging activity of Sesn may benefit to prevent various age-associated diseases and have clinical utility in diagnostic and therapeutic intervention.



中文翻译:

老化条件下雌二醇的保护反应

在细胞水平上的衰老以不受控的ROS形成,慢性炎症和对细胞应激的敏感性增加的形式表现出来。由于细胞中几种与年龄相关的病理变化,衰老通常被认为是多种疾病的危险因素。Sestrin(Sesn)是控制正常细胞生理的重要分子,并且在某些与年龄相关的细胞病理学进程中起重要作用。这项审查涉及结构,功能,调节,信号网络,和Sesn在与年龄相关的细胞病理生理学中的潜在作用。讨论了在压力条件下Sesn介导的细胞反应和救援机制。发现Sesn在调节细胞衰老中的确切生理作用将是有趣的。

更新日期:2020-09-30
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