Parkinson’s disease is characterized by decreased dopamine and increased beta-band oscillatory activity accompanying debilitating motor and mood impairments. Coordinate dopamine-beta opposition is considered a normative rule for basal ganglia function. We report a breakdown of this rule. We developed multimodal systems allowing the first simultaneous, chronic recordings of dopamine release and beta-band activity in the striatum of nonhuman primates during behavioral performance. Dopamine and beta signals were anticorrelated over seconds-long time frames, in agreement with the posited rule, but at finer time scales, we identified conditions in which these signals were modulated with the same polarity. These measurements demonstrated that task-elicited beta suppressions preceded dopamine peaks and that relative dopamine-beta timing and polarity depended on reward value, performance history, movement, and striatal domain. These findings establish a new view of coordinate dopamine and beta signaling operations, critical to guide novel strategies for diagnosing and treating Parkinson’s disease and related neurodegenerative disorders.

帕金森病的特征是多巴胺减少和 β 波段振荡活动增加，伴随着运动和情绪障碍的衰弱。协调多巴胺-β 对立被认为是基底神经节功能的规范规则。我们报告了这条规则的细目。我们开发了多模式系统，允许在行为表现期间首次同时、长期记录非人灵长类动物纹状体中的多巴胺释放和 β 带活动。多巴胺和 β 信号在数秒长的时间范围内是反相关的，这与假定的规则一致，但在更精细的时间尺度上，我们确定了这些信号以相同极性调制的条件。这些测量表明，任务引发的 β 抑制先于多巴胺峰值，并且相对的多巴胺-β 时间和极性取决于奖励价值、表现历史、运动和纹状体区域。这些发现建立了协调多巴胺和β信号传导操作的新观点，对于指导诊断和治疗帕金森病和相关神经退行性疾病的新策略至关重要。