Adiponectin gene (ADIPOQ) polymorphisms have been shown to affect adiponectin serum concentration and some have been associated with breast cancer (BC) risk. The aims of this study were to describe the frequency of single nucleotide polymorphisms (SNPs) of ADIPOQ in Mexican women with BC and to determine if they show an association with it. DNA samples from 397 patients and 355 controls were tested for the ADIPOQ gene SNPs: rs2241766 (GT) and rs1501299 (GT) by TaqMan allelic discrimination assay. Hardy–Weinberg equilibrium (HWE) was tested. Multiple SNP inheritance models adjusted by age and body mass index (BMI) were examined for the SNP rs1501299. We found that in the frequency analysis of rs1501299 without adjusting the BMI and age, the genotype distribution had a statistically significant difference (P = 0.003). The T allele was associated with a BC risk (OR, 1.99; 95% CI 1.13–3.51, TT vs. GG; OR, 1.53; 95% CI 1.12–2.09, GT vs. GG). The SNP rs2241766 was in HW disequilibrium in controls. In conclusion, the rs1501299 polymorphism is associated with a BC risk. Identification of the genotype of these polymorphisms in patients with BC can contribute to integrate the risk profile in both patients and their relatives as part of a comprehensive approach and increasingly more personalized medicine.

中文翻译：

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墨西哥东北部女性的ADIPOQ单核苷酸多态性与乳腺癌

脂联素基因（ADIPOQ）的多态性已被证明会影响脂联素的血清浓度，有些与乳腺癌（BC）的风险有关。这项研究的目的是描述墨西哥患有BC的女性ADIPOQ的单核苷酸多态性（SNP）的频率，并确定他们是否显示出与之相关。通过TaqMan等位基因歧视分析测试了来自397名患者和355名对照的DNA样品的ADIPOQ基因SNP：rs2241766（GT）和rs1501299（GT）。测试了Hardy-Weinberg平衡（HWE）。检查了针对年龄和体重指数（BMI）调整的多个SNP遗传模型的SNP rs1501299。我们发现，在不调整BMI和年龄的情况下对rs1501299进行频率分析时，基因型分布具有统计学上的显着差异（P = 0.003）。T等位基因与BC风险相关（OR为1.99； 95％CI为1.13-3.51，TT与GG； OR为1.53； 95％CI为1.12-2.09，GT与GG）。SNP rs2241766在对照组中处于硬件不平衡状态。总之，rs1501299多态性与BC风险相关。BC患者中这些多态性的基因型的鉴定可有助于整合患者及其亲属的风险概况，这是一种综合方法和越来越个性化的药物的一部分。