The solubility of thiabendazole (TBZ) in 12 organic solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, acetone, butanone, methyl acetate, ethyl acetate, n-butyl acetate, and acetonitrile) was determined by the gravimetric method from 283.15 to 323.15 K. The solubility in all selected solvents increases with increasing temperature and in acetonitrile changes much greater than that in other solvents as temperature increases. The solubility of TBZ is higher in alcohol and ketone solvents than those in esters and nitriles. Besides, the solubility is mainly related to the solvent polarity and cohesive energy density in nonalcohols and influenced by the complicated combination of many factors in alcohols. Further, the Apelblat model, λh model, and NRTL model were used to correlate the solubility of TBZ. The relative deviation is less than 2.23% with the modified Apelblat equation, which shows better fitting performance compared with other two models.

中文翻译：

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噻菌灵在283.15至323.15 K的12种纯有机溶剂中的溶解度测量和数据相关性

噻菌灵（TBZ）在12种有机溶剂（甲醇，乙醇，正丙醇，异丙醇，正丁醇，异丁醇，丙酮，丁酮，乙酸甲酯，乙酸乙酯，乙酸正丁酯和乙腈）中的溶解度确定重量法从283.15到323.15K。随着温度的升高，在所有选定溶剂中的溶解度都会增加，并且随着温度的升高，乙腈中的溶解度会比其他溶剂中的溶解度大得多。TBZ在醇和酮溶剂中的溶解度高于在酯和腈中的溶解度。此外，在非醇中的溶解度主要与溶剂的极性和内聚能密度有关，并受醇中多种因素复杂组合的影响。此外，Apelblat模型λh模型和NRTL模型用于关联TBZ的溶解度。修改后的Apelblat方程的相对偏差小于2.23％，与其他两个模型相比，它显示出更好的拟合性能。