Background. Increasing evidence states that the plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and apolipoprotein particles are regarded as the risk maker for cardiovascular heart disease. Nevertheless, the issue about whether Lp-PLA2 is associated with apolipoprotein particles in individuals who have been diagnosed as stable coronary artery disease (CAD) remains largely unexplored. Method. All 569 participants engaged in this research, who never took lipid-lowering drugs, had been divided into groups by the coronary angiography (CAG), namely, stable CAD: ; non-CAD: . The results concerning Lp-PLA2 levels were calculated by Elisa Kit, while apolipoprotein particles were measured by the department of laboratory. Results. The plasma concentration of Lp-PLA2 was remarkably higher in stable CAD group than the non-CAD group ( vs. , ). Pearson correlation analyses explained the plasma Lp-PLA2 concentration was correlated with apoB (, ) and apoB/apoA1 (, ), not associated with apoA1 (, ). Conversely, the association remains unobserved among non-CAD patients except apoA1. Moreover, multiple linear regression revealed the relations between Lp-PLA2 concentrations and apoB (, ), as well as apoB/apoA1 (, ), but not apoA1 (, ). After adjustment for several risk factors regarding CAD, like hypertension, gender, smoking, age, and diabetes mellitus, there had still been positive associations between the Lp-PLA2 concentration and apoB (, ), as well as apoB/apoA1 (, ). Conclusion. The plasma levels of Lp-PLA2 provide positively a key link with apoB, apoB/apoA-1 among stable CAD, denoting the communication between Lp-PLA2 and apolipoprotein particles in the state of CAD.

中文翻译：

---

稳定型冠状动脉疾病患者血浆脂蛋白相关磷脂酶 A2 浓度与载脂蛋白的关系

背景。越来越多的证据表明，血浆脂蛋白相关磷脂酶 A2 (Lp-PLA2) 水平和载脂蛋白颗粒被认为是心血管疾病的风险因素。然而，关于 Lp-PLA2 是否与被诊断为稳定型冠状动脉疾病 (CAD) 的个体的载脂蛋白颗粒相关的问题在很大程度上仍未得到探索。方法。参与这项研究的所有 569 名参与者，从未服用过降脂药物，均已通过冠状动脉造影 (CAG) 进行分组，即稳定型 CAD：; 非 CAD：. Lp-PLA2水平的结果由Elisa Kit计算，而载脂蛋白颗粒由实验室部门测量。结果。稳定 CAD 组血浆 Lp-PLA2 浓度显着高于非 CAD 组（对比, ）。Pearson 相关分析解释血浆 Lp-PLA2 浓度与 apoB 相关（, )和 apoB/apoA1 (, )，与 apoA1 无关 (, ）。相反，在除 apoA1 之外的非 CAD 患者中，这种关联仍未观察到。此外，多元线性回归揭示了 Lp-PLA2 浓度与 apoB 之间的关系（, )，以及 apoB/apoA1 (, )，但不是 apoA1 (, ）。在调整了与 CAD 相关的几个危险因素后，如高血压、性别、吸烟、年龄和糖尿病，Lp-PLA2 浓度与 apoB 之间仍然存在正相关关系。, )，以及 apoB/apoA1 (, ）。 结论。Lp-PLA2 的血浆水平与 apoB、apoB/apoA-1 在稳定 CAD 中呈正相关，表明 Lp-PLA2 与载脂蛋白颗粒在 CAD 状态下的交流。