To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.

中文翻译：

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COVID-19患者外周血CD4 +淋巴细胞和炎性细胞因子的变化

为了研究COVID-19患者外周血淋巴细胞亚型的变化和炎性细胞因子水平的临床价值，计算并观察了不同年龄组的淋巴细胞和CD4 +淋巴细胞的总数以及CD4 + / CD8 +淋巴细胞的比率。 COVID-19的患者。结果表明，COVID-19患者的淋巴细胞减少主要表现为CD4 + T淋巴细胞数量和CD4 + / CD8 +比值的降低。CD4 + T淋巴细胞数量减少和TNF-α和IL-6水平升高与COVID-19疾病的严重程度相关。