Background

For patients with single-sided deafness (SSD), restoration of binaural function via cochlear implant (CI) has been shown to improve speech understanding in noise. The objective of this study was to investigate changes in behavioral performance and cortical auditory responses following cochlear implantation.

Design

Prospective longitudinal study.

Setting

Tertiary referral center.

Methods

Six adults with SSD were tested before and 12 months post-activation of the CI. Six normal hearing (NH) participants served as experimental controls. Speech understanding in noise was evaluated for various spatial conditions. Cortical auditory evoked potentials were recorded with /ba/ stimuli in quiet and in noise. Global field power and responses at Cz were analyzed.

Results

Speech understanding in noise significantly improved with the CI when speech was presented to the CI ear and noise to the normal ear (p<0.05), but remained poorer than that of NH controls (p<0.05). N1 peak amplitude measure in noise significantly increased after CI activation (p<0.05), but remained lower than that of NH controls (p<0.05) at 12 months. After 12 months of CI experience, cortical responses in noise became more comparable between groups.

Conclusion

Binaural restoration in SSD patients via cochlear implantation improved speech performance noise and cortical responses. While behavioral performance and cortical auditory responses improved, SSD-CI outcomes remained poorer than that of NH controls in most cases, suggesting only partial restoration of binaural hearing.

中文翻译：

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人工耳蜗植入后单侧耳聋成年人对声音中皮层听觉反应的发展

背景

对于单侧耳聋（SSD）的患者，通过耳蜗植入（CI）恢复双耳功能已被证明可以改善语音对语音的理解。这项研究的目的是调查人工耳蜗植入后行为表现和皮质听觉反应的变化。

设计

前瞻性纵向研究。

设置

第三转诊中心。

方法

在激活CI之前和之后12个月对六名成人SSD进行了测试。六名正常听力（NH）参与者作为实验对照。在各种空间条件下评估了语音中的语音理解。/ ba /刺激在安静和噪音下记录皮质听觉诱发电位。分析了Cz的全局场强和响应。

结果

将语音呈现给CI耳朵和将噪声呈现给正常耳朵时，CI对噪声的语音理解有了显着改善（p <0.05），但仍然比NH对照弱（p <0.05）。CI激活后，噪声中的N1峰值幅度测量显着增加（p <0.05），但在12个月时仍低于NH对照的噪声（p <0.05）。经过12个月的CI经历后，两组之间的噪音皮层反应变得更具可比性。

结论

通过耳蜗植入，SSD患者的双耳修复改善了语音表现噪声和皮层反应。尽管行为表现和皮质听觉反应得到改善，但在大多数情况下，SSD-CI结局仍比NH对照差，表明双耳听力仅部分恢复。