Objectives Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) are frequently acquired during international travel, contributing to the global spread of antimicrobial resistance. Human-adapted ESBL-Ec are predicted to exhibit increased intestinal carriage duration, resulting in a higher likelihood of onward human-to-human transmission. Yet, bacterial determinants of increased carriage duration are unknown. Previous studies analysed small traveler cohorts, with short follow-up times, or did not employ high-resolution molecular typing, and were thus unable to identify bacterial traits associated with long-term carriage.

中文翻译：

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肠外致病性大肠杆菌 (ExPEC) 与旅行期间获得的产超广谱 β-内酰胺酶的大肠杆菌的长期携带有关

目的 产超广谱 β-内酰胺酶的大肠杆菌(ESBL-Ec) 经常在国际旅行中被感染，导致抗菌素耐药性在全球蔓延。预计人类适应的 ESBL-Ec 会增加肠道携带持续时间，从而导致更高的人际传播可能性。然而，增加运输持续时间的细菌决定因素是未知的。之前的研究分析了随访时间短或未采用高分辨率分子分型的小型旅行者队列，因此无法识别与长期携带相关的细菌特征。