The COVID-19 pandemic has been humbling for the biomedical community, pointing out as much about what we do not know as what we do. Among these learnings are lessons about immune-based measures to prevent or treat a new biothreat. This article summarizes lessons learned from two experimental approaches for passive immunity, convalescent plasma and monoclonal antibody therapy. Two early reports of outcomes, both of which appeared within hours of one another, reveal the importance of blending past learning with a forward-looking approach. These also present cautionary lessons as the world looks to new vaccines to help eradicate this deadly scourge.

中文翻译：

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哦，抗体的挫折！

COVID-19 大流行一直让生物医学界感到羞愧，它指出了我们所不知道的和我们所做的一样多。这些经验包括关于预防或治疗新生物威胁的基于免疫的措施的经验教训。本文总结了从两种被动免疫实验方法、恢复期血浆和单克隆抗体治疗中吸取的经验教训。两份早期的结果报告都在几个小时内出现，揭示了将过去的学习与前瞻性方法相结合的重要性。随着世界寻求新的疫苗来帮助根除这一致命的祸害，这些也提供了警示性的教训。