Traumatic brain injury (TBI) is a structural and physiological disruption of brain function caused by external forces. It is a major cause of death and disability for patients worldwide. TBI includes both primary and secondary impairments. Iron overload and ferroptosis highly involved in the pathophysiological process of secondary brain injury. Ferroptosis is a form of regulatory cell death, as increased iron accumulation in the brain leads to lipid peroxidation, reactive oxygen species (ROS) production, mitochondrial dysfunction and neuroinflammatory responses, resulting in cellular and neuronal damage. For this reason, eliminating factors like iron deposition and inhibiting lipid peroxidation may be a promising therapy. Iron chelators can be used to eliminate excess iron and to alleviate some of the clinical manifestations of TBI. In this review we will focus on the mechanisms of iron and ferroptosis involving the manifestations of TBI, broaden our understanding of the use of iron chelators for TBI. Through this review, we were able to better find novel clinical therapeutic directions for further TBI study.

颅脑外伤（TBI）是外力导致的大脑功能的结构和生理破坏。它是全世界患者死亡和残疾的主要原因。TBI包括主要和次要损害。铁超负荷和铁减少症高度参与继发性脑损伤的病理生理过程。肥大病是调节性细胞死亡的一种形式，因为大脑中铁的积累增加会导致脂质过氧化，活性氧（ROS）产生，线粒体功能障碍和神经炎症反应，从而导致细胞和神经元受损。因此，消除铁沉积和抑制脂质过氧化等因素可能是一种有前途的疗法。铁螯合剂可用于消除多余的铁并减轻TBI的某些临床表现。在本综述中，我们将重点研究涉及TBI表现的铁与铁的作用机理，拓宽我们对铁螯合剂用于TBI的理解。通过这次审查，我们能够更好地找到进一步的TBI研究的新的临床治疗方向。