Frontiers in Cellular and Infection Microbiology ( IF 5.7 ) Pub Date : 2020-08-21 , DOI: 10.3389/fcimb.2020.569022 Anna-Barbara Moscicki 1 , Baochen Shi 2 , Hazel Huang 2 , Emma Barnard 2 , Huiying Li 2
Persistent human papillomavirus (HPV) infections is necessary for the development of cervical cancers. Consequently, understanding the biologic mechanisms resulting in clearance is key in cancer prevention. Similar to other mucosal sites, it is expected that the local microbiome plays a significant role in shaping the immune response responsible for HPV clearance. Using cervical wash repository samples from a prospective study of HPV in women, this study investigates the microbiome and its associated inflammatory milieu during HPV 16 pre-acquisition, persistence and clearance states. For comparison, samples from women with no history of HPV ever during the study period were selected. We showed that 9 of 13 inflammatory cytokines were found to be significantly increased in the immediate post-clearance visit compared to the pre-acquisition or infection visits.
中文翻译:
宫颈阴道微生物组和相关的细胞因子谱在HPV 16采集,持续性和清除的前瞻性研究中
持续性人类乳头瘤病毒(HPV)感染对于宫颈癌的发展是必要的。因此,了解导致清除的生物学机制是预防癌症的关键。与其他粘膜部位相似,预计局部微生物组在塑造负责HPV清除的免疫反应中起重要作用。本研究使用对女性HPV进行前瞻性研究的宫颈洗液储存库样本,研究了HPV 16预采集,持久性和清除状态期间的微生物组及其相关的炎症环境。为了进行比较,选择了在研究期间从未有过HPV病史的女性样本。