The intestine is a particularly dynamic environment in which the host constantly interacts with trillions of symbiotic bacteria called the microbiota. Using quorum sensing (QS) communication, bacteria can coordinate their social behavior and influence host cell activities in a non-invasive manner. Nowadays, a large amount of research has greatly spurred the understanding of how bacterial QS communication regulates bacterial cooperative behaviors due to coexistence and host-microbe interactions. In this review, we discuss bacterial QS in the gut and its role in biofilm formation. As a biological barrier, the mucosal immune system can effectively prevent pathogenic microorganisms and other immunogenic components from entering the internal environment of the host. We focus on the relationship between biofilm and intestinal mucosal immunity, and how probiotic bacteria may regulate them. This review is to provide a theoretical basis for the development of new techniques including probiotics targeting the intestinal barrier function, thereby improving gut health.

肠道是一个特别动态的环境，宿主在该环境中不断与数万亿种称为微生物群的共生细菌相互作用。使用群体感应（QS）通信，细菌可以协调其社交行为并以非侵入性方式影响宿主细胞的活动。如今，大量研究极大地促进了人们对细菌QS交流如何通过共存和宿主-微生物相互作用来调节细菌协同行为的理解。在这篇综述中，我们讨论了肠道细菌QS及其在生物膜形成中的作用。作为生物屏障，粘膜免疫系统可以有效地防止病原微生物和其他免疫原性成分进入宿主的内部环境。我们专注于生物膜和肠道粘膜免疫之间的关系，以及益生菌如何调节它们。这篇综述为开发包括靶向肠屏障功能的益生菌在内的新技术提供理论依据，从而改善肠道健康。