Electrophilic groups that undergo sulfur-exchange chemistry with protein nucleophiles can serve as the functional basis of chemical proteomic probes. A new addition to this class, sulfuramidimidoyl fluoride (SAF), which can be included in an array of covalent small molecule probes, exhibits a unique reactivity profile with proteins.

中文翻译：

---

使用SAF（er）亲电子试剂靶向蛋白质

与蛋白质亲核试剂进行硫交换化学作用的亲电基团可以用作化学蛋白质组探针的功能基础。可添加到共价小分子探针阵列中的磺酰胺二酰亚胺基氟化物（SAF）是此类的新成员，它与蛋白质的反应性独特。