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MiR-370-5p inhibits the progression of breast cancer via targeting LUC7L3
Journal of Receptors and Signal Transduction ( IF 2.8 ) Pub Date : 2020-09-24 , DOI: 10.1080/10799893.2020.1819319
Kai Sang 1 , Tongbo Yi 1 , Xinxin Huang 2 , Chi Pan 1 , Jian Zhou 1 , Lei Yu 3
Affiliation  

Abstract

Breast cancer is one of the most common malignancies and one of the leading causes of cancer-induced mortality among women. Over the past decades, the occurrence of breast cancer has been a significant increase. As documented in numerous researches, microRNAs (miRNAs) play vital roles in a wide range of biological processes associated with the occurrence and development of breast cancer. Nevertheless, the role of miR-370-5p in breast cancer remains obscure, and the possible molecular regulatory mechanism needs to be further explored. In this study, our results delineated that miR-370-5p was downregulated in breast cancer tissues and cell lines. Besides, miR-370-5p overexpression suppressed cell proliferation and invasion in breast cancer. MiR-370-5p downregulation exerted an opposite result. In addition, LUC7L3 was identified as a target gene for miR-370-5p. Similar with the results induced by miR-370-5p overexpression, LUC7L3 knockdown attenuated the proliferation and invasion ability of breast cancer cells. Moreover, the alternation of LUC7L3 expression reversed the regulatory effects of miR-370-5p on cell phenotypes in breast cancer. Overall, miR-370-5p may exert antitumor effect on breast cancer. Hence, miR-370-5p may serve as a novel therapeutic marker for the treatment of patients with breast cancer.



中文翻译:

MiR-370-5p 通过靶向 LUC7L3 抑制乳腺癌的进展

摘要

乳腺癌是最常见的恶性肿瘤之一,也是女性因癌症死亡的主要原因之一。在过去的几十年里,乳腺癌的发生率已经显着增加。正如众多研究中所记录的,microRNA (miRNA) 在与乳腺癌的发生和发展相关的广泛生物过程中发挥着至关重要的作用。尽管如此,miR-370-5p在乳腺癌中的作用仍不清楚,可能的分子调控机制有待进一步探索。在这项研究中,我们的结果表明 miR-370-5p 在乳腺癌组织和细胞系中下调。此外,miR-370-5p过表达抑制乳腺癌细胞增殖和侵袭。MiR-370-5p 下调产生了相反的结果。此外,LUC7L3 被鉴定为 miR-370-5p 的靶基因。与 miR-370-5p 过表达诱导的结果相似,LUC7L3 敲低减弱了乳腺癌细胞的增殖和侵袭能力。此外,LUC7L3 表达的改变逆转了 miR-370-5p 对乳腺癌细胞表型的调节作用。总体而言,miR-370-5p 可能对乳腺癌发挥抗肿瘤作用。因此,miR-370-5p 可作为治疗乳腺癌患者的新型治疗标志物。miR-370-5p 可能对乳腺癌发挥抗肿瘤作用。因此,miR-370-5p 可作为治疗乳腺癌患者的新型治疗标志物。miR-370-5p 可能对乳腺癌发挥抗肿瘤作用。因此,miR-370-5p 可作为治疗乳腺癌患者的新型治疗标志物。

更新日期:2020-09-24
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