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Two possible ways to combine boron and gadolinium for Gd-guided BNCT. A concept
Phosphorus, Sulfur, and Silicon and the Related Elements ( IF 1.3 ) Pub Date : 2020-09-25 , DOI: 10.1080/10426507.2020.1804151
Sergey A. Anufriev 1 , Igor B. Sivaev 1 , Hiroyuki Nakamura 2
Affiliation  

Abstract Two ways of synthesis of theragnostic compounds for Gd-guided boron neutron capture therapy of cancer are proposed. The first way is based on modification of DO3A ligand, which a capable to form stable complexes with gadolinium, with attachment of boron-containing moieties and additional functional groups which can be used for conjugation with various biomacromolecules. The second way is based on the introduction of additional chelating groups into a boron-containing moiety—carborane-based ligand. It is expected that this will significantly improve the stability of the gadolinium bis(dicarbollide) complexes. GRAPHICAL ABSTRACT

中文翻译:

结合硼和钆用于 Gd 引导的 BNCT 的两种可能方法。一个概念

摘要 提出了两种用于 Gd 引导的硼中子俘获治疗癌症的治疗诊断化合物的合成方法。第一种方法是基于 DO3A 配体的修饰,该配体能够与钆形成稳定的复合物,并连接含硼部分和可用于与各种生物大分子结合的附加官能团。第二种方法基于将额外的螯合基团引入含硼部分——基于碳硼烷的配体。预计这将显着提高钆双(二碳化物)配合物的稳定性。图形概要
更新日期:2020-09-25
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