Neutrophils, which are traditionally regarded as a hallmark of inflammation, are also a member of the intratumoral immune cells. The roles of neutrophils in cancer development are diverse and undefined. So far, they are known to be involved in tumor initiation and tumor cell proliferation and metastasis. They show heterogeneity in both phenotypes and functions during early versus late stage of cancer development. Because they are also associated with the clinical outcomes of various types of solid tumors, cancer treatments that target neutrophils might be highly effective. In this review, we briefly cover the latest findings on the multiple roles of neutrophils in cancer development and point out the future directions as well.

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简述中性粒细胞在癌症发展中的作用

嗜中性粒细胞，传统上被认为是炎症的标志，也是肿瘤内免疫细胞的成员。中性粒细胞在癌症发展中的作用是多种多样且不确定的。迄今为止，已知它们与肿瘤的发生以及肿瘤细胞的增殖和转移有关。它们在癌症发展的早期和晚期都表现出不同的表型和功能。因为它们也与各种类型实体瘤的临床结果相关，所以针对嗜中性粒细胞的癌症治疗可能非常有效。在这篇综述中，我们简要介绍了中性粒细胞在癌症发展中的多重作用的最新发现，并指出了未来的方向。