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A theoretical model for the micron resolution spectral domain optical coherence tomography
Optics Communications ( IF 2.4 ) Pub Date : 2021-02-01 , DOI: 10.1016/j.optcom.2020.126478
Xiupin Wu , Wanrong Gao , Xiaoou Li , Jiayong Yan

Abstract . The resolution and effective imaging depth (EID) of spectral domain optical coherence tomography (OCT) are of great importance for visualizing the fine details of biological tissues. To this end, a theoretical model for the micron resolution spectral domain OCT was proposed with both the temporal coherence and the longitudinal spatial coherence considered. Based on the model, the parameters that influence the axial resolution, the signal intensity and the EID can be quantitatively analyzed. Among all the parameters the focusing effect of objective lens affects the signal intensity most due to the fast broadening of the effective point spread function (PSF) incident on the photosensitive surface of detector. It limits the EID defined by the signal fall-off less than 500 μ m . Similar to the dispersion mismatch between the sample arm and the reference arm, the NA of objective lens does influence the axial resolution in the form of convolution. A large NA, such as 0.4, would lead to multiple split peaks and severe side lobes in the axial PSF. The axial resolution could even be reduced to 11. 6 μ m , which is about ten times of the micron level resolution. For the EID defined by the micron axial resolution NA

中文翻译:

微米分辨率谱域光学相干断层扫描的理论模型

摘要 。光谱域光学相干断层扫描 (OCT) 的分辨率和有效成像深度 (EID) 对于可视化生物组织的精细细节非常重要。为此,提出了一种同时考虑时间相干性和纵向空间相干性的微米分辨率谱域 OCT 理论模型。基于该模型,可以定量分析影响轴向分辨率、信号强度和 EID 的参数。在所有参数中,物镜的聚焦效应对信号强度的影响最大,这是由于入射到探测器光敏表面的有效点扩散函数(PSF)的快速展宽。它将信号衰减定义的 EID 限制在 500 μm 以下。类似于样品臂和参考臂之间的色散失配,物镜的 NA 确实以卷积的形式影响轴向分辨率。较大的 NA(例如 0.4)会导致轴向 PSF 中出现多个分裂峰和严重的旁瓣。轴向分辨率甚至可以降低到11. 6 μ m ,大约是微米级分辨率的十倍。对于由微米轴向分辨率 NA 定义的 EID
更新日期:2021-02-01
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