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Inorganic nanoparticles in clinical trials and translations
Nano Today ( IF 17.4 ) Pub Date : 2020-12-01 , DOI: 10.1016/j.nantod.2020.100972
Hui Huang , Wei Feng , Yu Chen , Jianlin Shi

Abstract The development and application of nanotechnology-related knowledge and tools in modern medicine has been showing great potentials in elevating human’s living standards and improving mankind’s healthcare conditions via the prevention, early detection, diagnosis, treatment and follow-up of various diseases. The significant progress of nanomedicine has been achieved by the exploration of nanoparticulate formulations for theranostic purposes in a living organism. Among abundant nanoparticles, inorganic nanoparticles feature distinctive physiochemical properties and biological effects, with which conventional organic counterparts are typically not endowed. In the past thirty years, to be true, very few inorganic nanomaterials have been made from bench to bedside translation. It is thus more vital than ever for the scientific community to make ever-greater efforts to realize their clinical translations. Therefore, this review highlights and discusses such a compelling topic on the clinical trials and translation of inorganic nanoparticles. We will provide an update of the current progresses in clinic-relevant applications in terms of inorganic nanoparticles being used as detecting tools, contrast agents as well as therapeutic vehicles. Especially, the crucial challenges and future prospects in translating inorganic nanoparticles into clinical practices are highlighted and outlooked. This review aims to bring the issues of clinical relevance and translatability of inorganic nanoparticles to the forefront, which is the primary impetus, and also critically important, for the development of inorganic nanoparticles-based nanobiotechnology and nanomedicine.

中文翻译:

临床试验和翻译中的无机纳米粒子

摘要 纳米技术相关知识和工具在现代医学中的发展和应用,通过对各种疾病的预防、早期发现、诊断、治疗和随访,在提高人类生活水平和改善人类健康状况方面显示出巨大的潜力。通过探索用于生物体治疗诊断目的的纳米颗粒制剂,纳米医学取得了重大进展。在丰富的纳米粒子中,无机纳米粒子具有独特的理化特性和生物效应,而传统的有机纳米粒子通常不具备这些特性。在过去的 30 年中,确实很少有无机纳米材料能够从工作台到床边转换。因此,科学界比以往任何时候都更加努力实现其临床转化。因此,这篇综述强调并讨论了一个关于无机纳米粒子的临床试验和转化的引人注目的话题。我们将在无机纳米粒子用作检测工具、造影剂和治疗载体方面提供临床相关应用当前进展的最新情况。特别是,突出并展望了将无机纳米粒子转化为临床实践的关键挑战和未来前景。本综述旨在将无机纳米粒子的临床相关性和可转化性问题带到前沿,这是主要推动力,也是至关重要的,
更新日期:2020-12-01
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