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Evaluation of patients with late-onset and medically refractory temporal lobe epilepsy with mesial temporal sclerosis
Clinical Neurology and Neurosurgery ( IF 1.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.clineuro.2020.106209
Selahattin Ayas 1 , Selin Yağcı Kurtish 2 , Taner Tanrıverdi 2 , Seher Naz Yeni 1
Affiliation  

OBJECTIVES Our study aims to compare demographics, clinical features and postsurgical outcomes between early and late-onset patients with medically refractory temporal lobe epilepsy (TLE) related to mesial temporal sclerosis (MTS). PATIENTS AND METHODS Seventy-one patients admitting to the Epilepsy Clinic of Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine between 1995-2015, who were diagnosed with refractory TLE related to MTS, were included in our study. All of these patients were resistant to medical treatment, and thus candidates for, or underwent surgery, and had no pathology other than MTS in their cranial magnetic resonance imaging (MRI). Based on previous studies, those patients were divided into two categories as "early-onset" and "late-onset", according to the age-onset of afebrile recurrent seizures, where the cutoff was determined as 20 years. Demographics, clinical features, and postsurgical outcomes were compared between both groups. RESULTS Fifty-three patients included in our study had early-onset MTS-TLE, and 18 patients had late-onset MTS-TLE. Demographics, clinical features, characteristics of electroencephalography (EEG), MRI, PET MRI/CT, neuropsychometric test (NPT) and postsurgical outcomes were similar in both groups. CONCLUSION In both the early-onset and late-onset groups, the presence of similar demographics, clinical features, and postoperative outcomes have suggested that the course of the disease and the success of surgical treatment were not associated with the age-onset of seizures in TLE related to MTS.

中文翻译:

迟发性和药物难治性颞叶癫痫伴颞叶内侧硬化患者的评估

目的 我们的研究旨在比较与内侧颞叶硬化 (MTS) 相关的医学难治性颞叶癫痫 (TLE) 早发和晚发患者的人口统计学、临床特征和术后结果。患者和方法 我们的研究纳入了 1995-2015 年间入住伊斯坦布尔大学-Cerrahpasa 医学院癫痫诊所的 71 名被诊断患有与 MTS 相关的难治性 TLE 的患者。所有这些患者都对药物治疗有抵抗力,因此适合或接受了手术,并且在他们的颅核磁共振成像 (MRI) 中没有除 MTS 以外的其他病理。根据以往的研究,这些患者根据无热性反复发作的发病年龄分为“早发型”和“晚发型”两类,其中截止时间被确定为 20 年。比较两组的人口统计学、临床特征和术后结果。结果 我们研究中包括的 53 名患者患有早发性 MTS-TLE,18 名患者患有迟发性 MTS-TLE。两组的人口统计学、临床特征、脑电图 (EEG)、MRI、PET MRI/CT、神经心理测试 (NPT) 和术后结果的特征相似。结论在早发和晚发组中,相似的人口统计学、临床特征和术后结果的存在表明疾病的进程和手术治疗的成功与癫痫发作的年龄无关。与 MTS 相关的 TLE。并比较两组的术后结果。结果 我们研究中包括的 53 名患者患有早发性 MTS-TLE,18 名患者患有迟发性 MTS-TLE。两组的人口统计学、临床特征、脑电图 (EEG)、MRI、PET MRI/CT、神经心理测试 (NPT) 和术后结果的特征相似。结论在早发和晚发组中,相似的人口统计学、临床特征和术后结果的存在表明疾病的进程和手术治疗的成功与癫痫发作的年龄无关。与 MTS 相关的 TLE。并比较两组的术后结果。结果 我们研究中包括的 53 名患者患有早发性 MTS-TLE,18 名患者患有迟发性 MTS-TLE。两组的人口统计学、临床特征、脑电图 (EEG)、MRI、PET MRI/CT、神经心理测试 (NPT) 和术后结果的特征相似。结论在早发和晚发组中,相似的人口统计学、临床特征和术后结果的存在表明疾病的进程和手术治疗的成功与癫痫发作的年龄无关。 TLE 与 MTS 相关。两组的脑电图 (EEG)、MRI、PET MRI/CT、神经心理测试 (NPT) 和术后结果的特征相似。结论在早发和晚发组中,相似的人口统计学、临床特征和术后结果的存在表明疾病的进程和手术治疗的成功与癫痫发作的年龄无关。与 MTS 相关的 TLE。两组的脑电图 (EEG)、MRI、PET MRI/CT、神经心理测试 (NPT) 和术后结果的特征相似。结论在早发和晚发组中,相似的人口统计学、临床特征和术后结果的存在表明疾病的进程和手术治疗的成功与癫痫发作的年龄无关。与 MTS 相关的 TLE。
更新日期:2020-11-01
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