Engineered nanoparticles (ENPs) are now being applied across a range of disciplines, and as a result numerous studies have now assessed ENP-related bioeffects. Among them, ENP-induced epigenetic changes including DNA methylation, histone modifications, and miRNA-mediated regulation of gene expression have recently attracted attention. In this review, we describe the diversity of ENP-induced epigenetic changes, focusing on their interplay with related functional biological events, especially oxidative stress, MAPK pathway activation, and inflammation. In doing so, we highlight the underlying mechanisms and biological effects of ENP-induced epigenetic changes. We also summarize how high-throughput technologies have helped to uncover ENP-induced epigenetic changes. Finally, we discuss future perspectives and the challenges related to ENP-induced epigenetic changes that still need to be addressed.

工程纳米颗粒（ENPs）现在正被应用到许多学科中，因此，大量研究现已评估了ENP相关的生物效应。其中，ENP诱导的表观遗传变化包括DNA甲基化，组蛋白修饰和miRNA介导的基因表达调控最近引起了人们的关注。在这篇综述中，我们描述了ENP诱导的表观遗传学变化的多样性，重点是它们与相关功能生物学事件（尤其是氧化应激，MAPK途径激活和炎症）的相互作用。在此过程中，我们重点介绍了ENP诱导的表观遗传变化的潜在机制和生物学效应。我们还总结了高通量技术如何帮助发现ENP诱导的表观遗传学变化。最后，