Abstract

The possibility of employing the method of mass spectrometry with matrix-assisted laser desorption/ionization (MALDI) for the rapid detection of carboxyl-containing nonsteroidal anti-inflammatory drugs has been studied. Comparison of the results obtained using the previously described and newly proposed as matrix compounds 4-(dimethylamino)benzaldehyde and N,N-dimethyl-p-phenylenediamine, showed that the latter provide the registration of mass spectra containing intense peaks of deprotonated molecules of all drugs used in the work. Comparison of the time required for their detection by various mass spectrometric methods has shown that MALDI mass spectrometry provides the highest performance in streaming analysis.

中文翻译：

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MALDI质谱法检测含羧基非甾体抗炎药的新基质化合物

摘要

已经研究了采用质谱法和基质辅助激光解吸/电离（MALDI）方法快速检测含羧基的非甾体类抗炎药的可能性。比较使用先前描述和新提出的基质化合物4-（二甲基氨基）苯甲醛和N，N-二甲基-对苯二胺获得的结果，结果表明后者提供了包含所有去质子化分子强峰的质谱配准工作中使用的药物。通过各种质谱方法检测其所需时间的比较表明，MALDI质谱在流分析中提供了最高的性能。