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Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids
Phytochemistry Reviews ( IF 7.7 ) Pub Date : 2020-09-25 , DOI: 10.1007/s11101-020-09723-3
Xian-Hui Jia 1 , Huan-Xin Zhao 1 , Cheng-Lin Du 1 , Wen-Zhao Tang 1 , Xiao-Jing Wang 1
Affiliation  

Naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids (PIAs and PQAs) are two small groups of herbal metabolites sharing a similar pentacyclic structure with a highly oxygenated phenanthrene moiety fused with a saturated or an unsaturated N-heterocycle (indolizidine/quinolizidine moieties). Natural PIAs and PQAs only could be obtained from finite plant families (such as Asclepiadaceae, Lauraceae and Urticaceae families, etc.). Up to date, more than one hundred natural PIAs, while only nine natural PQAs had been described. PIA and PQA analogues have been applied to the development of potent anticancer agents all along because of their excellent cytotoxic activity. However, in the last two decades, other great biological properties, such as anti-inflammatory and antiviral activities were revealed successively by different pharmacological assays. Especially because of their potent antiviral activity against coronavirus (TGEV, SARS CoV and MHV) and tobacco mosaic virus, PIA and PQA analogues have attracted much pharmaceutical attention again, some of them have been used to present interesting targets for total or semi synthesis, and structure–activity relationship (SAR) study for the development of antiviral agents. In this review, natural PIA and PQA analogues obtained in the last two decades with their herbal origins, key spectroscopic characteristics for structural identification, biological activity with possible SARs and application prospects were systematically summarized. We hope this paper can stimulate further investigations on PIA and PQA analogues as an important source for potential drug discovery.



中文翻译:

可能的药物应用可以从天然存在的菲并喹啉生物碱和菲喹啉生物碱开发

天然存在的菲并喹啉生物碱 (PIA 和 PQA) 是两组具有相似五环结构的草本代谢物,具有高度氧化的菲部分与饱和或不饱和的N-杂环(indolizidine/quinolizidine 部分)。天然 PIAs 和 PQAs 只能从有限的植物科(如木兰科、月桂科和荨麻科等)中获得。迄今为止,已有一百多种天然 PIA,而仅描述了九种天然 PQA。由于 PIA 和 PQA 类似物具有优异的细胞毒活性,它们一直被用于开发有效的抗癌药物。然而,在过去的二十年中,其他重要的生物学特性,如抗炎和抗病毒活性,通过不同的药理学试验相继揭示。特别是由于对冠状病毒(TGEV、SARS CoV 和 MHV)和烟草花叶病毒具有强大的抗病毒活性,PIA 和 PQA 类似物再次引起了制药业的广泛关注,其中一些已被用于呈现有趣的全合成或半合成靶标,以及用于开发抗病毒药物的构效关系 (SAR) 研究。在这篇综述中,系统总结了过去 20 年获得的天然 PIA 和 PQA 类似物及其草药来源、结构鉴定的关键光谱特征、可能存在 SAR 的生物活性和应用前景。我们希望本文能够激发对 PIA 和 PQA 类似物的进一步研究,作为潜在药物发现的重要来源。系统总结了结构识别的关键光谱特征、可能存在SAR的生物活性和应用前景。我们希望本文能够激发对 PIA 和 PQA 类似物的进一步研究,作为潜在药物发现的重要来源。系统总结了结构识别的关键光谱特征、可能存在SAR的生物活性和应用前景。我们希望本文能够激发对 PIA 和 PQA 类似物的进一步研究,作为潜在药物发现的重要来源。

更新日期:2020-09-25
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