Abstract—The pharmacological effects of intraperitoneal (i.p.) and intranasal (i.n.) administration of the peptides selank (300 µg/kg/day), noopept (1 mg/kg/day), and semax (0.6 mg/kg/day), which are known to possess anxiolytic and nootropic properties, were compared by studying the elevated-plus-maze (EPM) behavior of inbred BALB/c and C57BL/6 mice, and studying their effects on NMDA- and mGluII- receptors in the brain. Semax, noopept, and selank administered via both routes improved exploratory activity and reduced anxiety in BALB/c mice, but the anxiolytic efficiency was higher after intraperitoneal injection and the nootropic efficiency was higher after intranasal administration. In C57BL/6 mice, semax, noopept, and selank did not affect the efficiency of exploratory behavior or anxiety after administration via either route, except for i.p. injection of semax, which showed a greater anxiogenic effect compared to intranasal administration. In BALB/c mice, i.p. administration of noopept and i.n. administration of selank increased the density of NMDA-receptors in the hippocampus and i.n. administration of noopept and semax reduced their density, with no effect on mGluII-receptors. In C57BL/6 mice, i.p. semax and i.n. noopept reduced the number of NMDA-receptor binding sites, and i.p. noopept and semax administered via either route reduced the density of mGluII-receptors in the cerebral cortex.

摘要-腹膜内（ip）和鼻内（in）施用肽的药理作用分别为：倾斜（300 µg / kg /天），无肽（1 mg / kg /天）和semax（0.6 mg / kg /天），通过研究近交BALB / c和C57BL / 6小鼠的高迷宫（EPM）行为，以及研究它们对大脑中NMDA和mGluII-受体的影响，对已知具有抗焦虑和促智作用的物质进行了比较。通过这两种途径给药的Semax，noopept和selank均改善了BALB / c小鼠的探索活性并减少了焦虑，但是腹膜内注射后的抗焦虑效率更高，鼻内给药后的促智效率更高。在C57BL / 6小鼠中，除了ip以外，semax，noopept和selank在通过任一途径给药后均不影响探索行为或焦虑的效率 注射semax，与鼻内给药相比，显示出更大的抗焦虑作用。在BALB / c小鼠中，ip给予noopept和selank可以增加海马中NMDA受体的密度，而noopept和semax可以降低其密度，而对mGluII-受体没有影响。在C57BL / 6小鼠中，ip semax和noopept降低了NMDA受体结合位点的数量，ip noopept和semax通过任一途径给药均降低了大脑皮层中mGluII-受体的密度。对mGluII受体无影响。在C57BL / 6小鼠中，ip semax和noopept降低了NMDA受体结合位点的数量，ip noopept和semax通过任一途径给药均降低了大脑皮层中mGluII-受体的密度。对mGluII受体无影响。在C57BL / 6小鼠中，ip semax和noopept降低了NMDA受体结合位点的数量，ip noopept和semax通过任一途径给药均降低了大脑皮层中mGluII-受体的密度。