Nanotechnology has been exploited as a great scientific area especially in stating scenarios in drug discovery. In the present study, biosynthesized selenium nanoparticles (SeNPs) were prepared by the filtrate of Spirulina platensis after ultrasonication of their biomass. The biosynthesized SeNPs was characterized by using ultra-violet visible, Fourier transform infra-red spectroscopy, dynamic light scattering, and transmission electron microscope (TEM). The zeta potential of Biogenic SeNPs was -32.9 ± 8.12 mv that caused their stability. TEM micrographs elucidated the spherical shape of Biogenic SeNPs with a mean average size of 79.40 ± 44.26 nm. Biogenic SeNPs showed potential antimicrobial activity against gram-negative bacteria and yeast fungi C. albicans ATCC10231. No toxic effect was observed for SeNPs on normal kidney and liver cell lines. Biogenic SeNPs could be considered as a hopeful choice for future therapeutic applications because of their good biocompatibility and reactivity.

中文翻译：

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钝顶螺旋藻生物合成硒纳米颗粒的细胞毒性和抗菌效率

纳米技术已被开发为一个伟大的科学领域，特别是在药物发现的陈述场景中。在本研究中，生物合成的硒纳米粒子 (SeNPs) 是由螺旋藻生物质超声处理后的滤液制备的。通过使用紫外可见光、傅里叶变换红外光谱、动态光散射和透射电子显微镜 (TEM) 对生物合成的 SeNP 进行了表征。生物 SeNP 的 zeta 电位为 -32.9 ± 8.12 mv，这导致它们的稳定性。TEM 显微照片阐明了生物 SeNP 的球形形状，平均尺寸为 79.40 ± 44.26 nm。生物 SeNP 显示出对革兰氏阴性细菌和酵母真菌 C. albicans ATCC10231 的潜在抗菌活性。未观察到 SeNP 对正常肾脏和肝脏细胞系的毒性作用。