Neurodegeneration disorders are complex and multifaceted, leading to many chronic diseases, like Parkinson's disease (PD). Electrolytes imbalance has a significant role in the pathophysiology of neurological disorders, which might serve as a bio-indicator of these problems. In the present study, the disturbances of the electrolytes, calcium (Ca), magnesium (Mg), sodium (Na), and potassium (K), concentrations, and their correlation with biochemical parameters of PD patients at three different age groups (15 to 75 years) and stages were studied. The all resulted data of PD patients was compared with non-diseased/referents (PD) of same age groups. The biological samples (scalp hair, serum and plasma) were collected from Parkinson's disease (PD) patients, diagnosed at three stages, early (15 to 30 years), mild (30 to 60 years) and severe (61 to 75 years). The electrolyte concentrations were measured after acid digested biological samples using flame atomic absorption spectrometry. The precision of the digestion method was verified by matrices matched certified reference materials. The resulted data indicated that the contents of Ca and Mg were found to be higher in scalp hair samples of PD patients at early to severe stages as compared with those results obtained from referents. The concentrations of Na and K were found to be lower for all PD patients groups as compared with referents; however, the difference was not significant (p < 0.05). Electrolytes levels in blood serum and plasma were found to be lower in all patients than healthy groups (p < 0.01). These results suggest a disturbance in the electrolytes homeostasis during the different clinical stages of PD, whereas the higher disturbance was observed in patients at severe stage (61 to 75 years).

中文翻译：

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与帕金森病临床分期相关的头皮毛发和血液样本中的钠、钾、钙和镁。

神经退行性疾病是复杂和多方面的，导致许多慢性疾病，如帕金森病 (PD)。电解质失衡在神经系统疾病的病理生理学中具有重要作用，可作为这些问题的生物指标。在本研究中，三个不同年龄组的 PD 患者的电解质紊乱、钙 (Ca)、镁 (Mg)、钠 (Na) 和钾 (K)、浓度及其与生化参数的相关性 (15到 75 岁）和阶段进行了研究。将 PD 患者的所有结果数据与相同年龄组的非疾病/参照物 (PD) 进行比较。生物样本（头皮毛发、血清和血浆）采集自帕金森病（PD）患者，分三个阶段确诊，早期（15 至 30 岁）、轻度（30 至 60 岁）和重度（61 至 75 岁）。使用火焰原子吸收光谱法在酸消化生物样品后测量电解质浓度。消解方法的精密度通过基质匹配的有证标准物质进行验证。结果数据表明，与从参照物获得的结果相比，在早期至重度阶段的 PD 患者的头皮毛发样本中发现 Ca 和 Mg 的含量更高。与参照组相比，所有 PD 患者组的 Na 和 K 浓度均较低；然而，差异并不显着（p < 0.05）。发现所有患者的血清和血浆中的电解质水平低于健康组（p < 0.01）。