OBJECTIVE To investigate oculomotor impairment in subtypes of progressive supranuclear palsy (PSP) and its associations with clinical features and regional brain volumes in PSP. METHODS We compared the video-oculography (VOG) findings of 123 PSP patients, consisting of 66 PSP-Richardson syndrome (PSP-RS), 28 PSP-parkinsonism (PSP-P), and 29 PSP-progressive gait freezing (PSP-PGF), along with 80 Parkinson's disease (PD) patients. We also investigated the associations of the VOG results with clinical features (disease duration, PSP rating scales [PSPRS] scores for dysphagia and postural stability) in the subtypes of PSP patients and with regional volumes in the brainstem, including the midbrain, pons, medulla, and the superior cerebellar peduncle (SCP), among the patients who had MRI images at the time of VOG (30 PSP). RESULTS All of the three subtypes of PSP patients showed slower vertical saccades and smooth pursuit than that of the PD patients (adjusted p < 0.05). Among the PSP subtypes, saccadic peak velocity, saccadic accuracy, and pursuit gain were significantly decreased in patients with the PSP-RS compared to those with the PSP-PGF (adjusted p < 0.05). In multiple linear regression model, vertical saccadic velocity, latency, accuracy, and pursuit gain were associated with the PSPRS score for dysphagia (adjusted p < 0.05), and a decrease in vertical saccadic speed and accuracy was associated with SCP atrophy (corrected p < 0.05). CONCLUSIONS This study demonstrated the severity of oculomotor dysfunction in differentiating the subtypes of PSP and its significant relationships with the dysphagia symptom and SCP volume in PSP.

中文翻译：

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在进行性核上性麻痹的临床亚型中眼球运动和与区域性脑萎缩的关联。

目的 研究进行性核上性麻痹 (PSP) 亚型的动眼神经损伤及其与 PSP 临床特征和区域脑容量的关系。方法 我们比较了 123 名 PSP 患者的视频眼影 (VOG) 结果，包括 66 名 PSP-理查森综合征 (PSP-RS)、28 名 PSP-帕金森综合征 (PSP-P) 和 29 名 PSP-进行性步态冻结 (PSP-PGF) )，以及 80 名帕金森氏病 (PD) 患者。我们还研究了 VOG 结果与 PSP 患者亚型的临床特征（疾病持续时间、吞咽困难和姿势稳定性的 PSP 评分量表 [PSPRS] 评分）以及脑干区域体积（包括中脑、脑桥、髓质）的关联和小脑上脚 (SCP)，在 VOG (30 PSP) 时有 MRI 图像的患者中。结果 PSP 患者的三个亚型均表现出比 PD 患者更慢的垂直扫视和平滑的追踪（调整后的 p < 0.05）。在 PSP 亚型中，与 PSP-PGF 患者相比，PSP-RS 患者的扫视峰值速度、扫视准确度和追踪增益显着降低（调整后的 p < 0.05）。在多元线性回归模型中，垂直扫视速度、潜伏期、准确度和追踪增益与吞咽困难的 PSPRS 评分相关（调整后的 p < 0.05），垂直扫视速度和准确度的降低与 SCP 萎缩相关（修正后的 p < 0.05） 0.05）。结论 本研究证明了动眼神经功能障碍在区分 PSP 亚型方面的严重程度及其与 PSP 中吞咽困难症状和 SCP 体积的显着关系。