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Human Exfoliated Deciduous Teeth Stem Cells: Features and Therapeutic Effects on Neurogenerative and Hepatobiliary-pancreatic Diseases
Current Stem Cell Research & Therapy ( IF 2.7 ) Pub Date : 2021-06-30 , DOI: 10.2174/1574888x15999200918105623
Nurul W A Wahab 1 , Rhanye M Guad 2 , Vetriselvan Subramaniyan 3 , Ismail M Fareez 4 , Ker W Choy 5 , Srinivasa R Bonam 6 , Chandrasekaran Selvaraju 7 , Maw S Sim 1 , Subash C B Gopinath 8 , Yuan S Wu 9
Affiliation  

Stem cells can multiply into more cells with similar types in an undifferentiated form and differentiate into other types of cells. The great success and key essence of stem cell technology is the isolation of high-quality Mesenchymal Stem Cells (MSCs) with high potency, either with multipotent or pluripotent property. In this line, Stem cells from Human Exfoliated Deciduous teeth (SHEDs) are highly proliferative stem cells from dental pulp and have multipoint differentiation capacity. These cells play a pivotal role in regenerative medicine, such as cell repair associated with neurodegenerative, hepatobiliary, and pancreatic diseases. In addition, stem cell therapy has been widely used to regulate immune response and repair of tissue lesions. This overview captured the differential biological characteristics, and the potential role of stem cell technology and paid special attention to human welfare SHEDs in eliminating the above-mentioned diseases. This review provides further insights into stem cell technology by expanding the therapeutic potential of SHEDs in tissue engineering and cell organ repairs.



中文翻译:

人脱落乳牙干细胞:神经性和肝胆胰疾病的特征和治疗效果

干细胞可以以未分化的形式增殖成更多类型相似的细胞,并分化成其他类型的细胞。干细胞技术的巨大成功和关键本质是分离出具有多能或多能特性的高效能的高质量间充质干细胞 (MSC)。在该系列中,来自人类脱落乳牙 (SHED) 的干细胞是来自牙髓的高度增殖干细胞,具有多点分化能力。这些细胞在再生医学中发挥着关键作用,例如与神经退行性疾病、肝胆和胰腺疾病相关的细胞修复。此外,干细胞疗法已被广泛用于调节免疫反应和修复组织病变。该概述捕获了差异生物学特征,以及干细胞技术的潜在作用,并特别关注人类福利 SHED 在消除上述疾病方面。本综述通过扩大 SHED 在组织工程和细胞器官修复中的治疗潜力,提供了对干细胞技术的进一步见解。

更新日期:2021-07-26
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