Electrical impedance tomography is clinically used to trace ventilation related changes in electrical conductivity of lung tissue. Estimating regional pulmonary perfusion using electrical impedance tomography is still a matter of research. To support clinical decision making, reliable bedside information of pulmonary perfusion is needed. We introduce a method to robustly detect pulmonary perfusion based on indicator-enhanced electrical impedance tomography and validate it by dynamic multidetector computed tomography in two experimental models of acute respiratory distress syndrome. The acute injury was induced in a sublobar segment of the right lung by saline lavage or endotoxin instillation in eight anesthetized mechanically ventilated pigs. For electrical impedance tomography measurements, a conductive bolus (10% saline solution) was injected into the right ventricle during breath hold. Electrical impedance tomography perfusion images were reconstructed by linear and normalized Gauss-Newton reconstruction on a finite element mesh with subsequent element-wise signal and feature analysis. An iodinated contrast agent was used to compute pulmonary blood flow via dynamic multidetector computed tomography. Spatial perfusion was estimated based on first-pass indicator dilution for both electrical impedance and multidetector computed tomography and compared by Pearson correlation and Bland-Altman analysis. Strong correlation was found in dorsoventral (r = 0.92) and in right-to-left directions (r = 0.85) with good limits of agreement of 8.74% in eight lung segments. With a robust electrical impedance tomography perfusion estimation method, we found strong agreement between multidetector computed and electrical impedance tomography perfusion in healthy and regionally injured lungs and demonstrated feasibility of electrical impedance tomography perfusion imaging.

中文翻译：

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通过电阻抗和计算机断层扫描在实验性ARDS中进行区域肺灌注分析。

电阻抗断层扫描在临床上用于追踪通气相关的肺组织电导率变化。使用电阻抗层析成像技术估算局部肺血流灌注仍是一个研究问题。为了支持临床决策，需要可靠的床旁肺灌注信息。我们介绍了一种基于指标增强的电阻抗层析成像技术来可靠地检测肺动脉灌注的方法，并通过动态多探测器计算机层析成像技术在两种急性呼吸窘迫综合征实验模型中进行了验证。在八只麻醉的机械通气猪中，通过盐水灌洗或内毒素滴注在右肺下叶下段诱发了急性损伤。对于电阻抗层析成像测量，在屏气过程中，将导电推注（10％盐溶液）注入右心室。通过在有限元网格上进行线性和归一化的高斯-牛顿重建，并随后进行逐元素信号和特征分析，重建电阻抗层析成像灌注图像。使用碘化造影剂通过动态多探测器计算机断层扫描技术计算肺血流量。基于针对电阻抗和多探测器计算机断层扫描的首过指示剂稀释度估计空间灌注，并通过Pearson相关性和Bland-Altman分析进行比较。在背腹（r = 0.92）和从右到左方向（r = 0.85）发现强相关性，在八个肺段中，良好的一致性限制为8.74％。利用强大的电阻抗层析成像灌注估计方法，