A systematic review of relevant studies that determined the dose response relationship (DRR) for the hematopoietic (H) acute radiation syndrome (ARS) in the canine relative to radiation quality of mixed neutron:gamma radiations, dose rate, and exposure uniformity relative to selected reference radiation exposure has not been performed. The datasets for rhesus macaques exposure to mixed neutron:gamma radiation are used herein as a species comparative reference to the canine database. The selection of data cohorts was made from the following sources: Ovid Medline (1957-present), PubMed (1954-present), AGRICOLA (1976-present), Web of Science (1954-present), and US HHS RePORT (2002-present). The total number of hits across all search sites was 3,077. Several referenced, unpublished, non-peer reviewed government reports were unavailable for review. Primary published studies using canines, beagles, and mongrels were evaluated to provide an informative and consistent review of mixed neutron:gamma radiation effects to establish the DRRs for the H-ARS. Secondary and tertiary studies provided additional information on the hematologic response or the effects on hematopoietic progenitor cells, radiation dosimetry, absorbed dose, and organ dose. The LD50/30 values varied with neutron quality, exposure aspect, and mixed neutron:gamma ratio. The reference radiation quality varied from 250 kVp or 1-2 MeV x radiation and Co gamma radiation. A summary of a published review of a data set describing the DRR in rhesus macaques for mixed neutron:gamma radiation exposure in the H-ARS is included for a comparative reference to the canine dataset. The available evidence provided a reliable and extensive database that characterized the DRR for the H-ARS in canines and young rhesus macaques exposed to mixed neutron:gamma radiations of variable energy relative to 250 kVp, 1-2 MeV x radiation and Co gamma, and uniform and non-uniform total-body irradiation without the benefit of medical management. The mixed neutron:gamma radiation showed an energy-dependent RBE of ~ 1.0 to 2.0 relative to reference radiation exposure within both species. A marginal database described the DRR for the gastrointestinal (GI)-ARS. Medical management showed benefit in both species relative to the mixed neutron:gamma as well as exposure to reference radiation. The DRR for the H-ARS was characterized by steep slopes and relative LD50/30 values that reflected the radiation quality, exposure aspect, and dose rate over a range in time from 1956-2012.

中文翻译：

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犬类和非人类灵长类动物造血急性辐射综合征 (H-ARS) 的系统评价：急性混合中子/伽马与参考质量辐射。

对确定犬类造血 (H) 急性辐射综合征 (ARS) 的剂量反应关系 (DRR) 与混合中子：γ 辐射的辐射质量、剂量率和相对于所选辐射均匀性的相关研究的系统评价未进行参考辐射暴露。恒河猴暴露于混合中子：伽马辐射的数据集在本文中用作犬类数据库的物种比较参考。数据队列的选择来自以下来源：Ovid Medline（1957 年至今）、PubMed（1954 年至今）、AGRICOLA（1976 年至今）、Web of Science（1954 年至今）和美国 HHS 报告（2002 年至今）当下）。所有搜索网站的总点击量为 3,077。一些参考的、未发表的、未经同行评审的政府报告无法进行审查。对使用犬科动物、小猎犬和杂种犬的初步发表的研究进行了评估，以提供对混合中子：伽马辐射效应的信息性和一致的审查，以确定 H-ARS 的 DRR。二级和三级研究提供了关于血液学反应或对造血祖细胞、辐射剂量测定、吸收剂量和器官剂量影响的更多信息。LD50/30 值随中子质量、暴露方面和混合中子：伽马比而变化。参考辐射质量从 250 kVp 或 1-2 MeV x 辐射和 Co 伽马辐射不等。包含已发表的对 H-ARS 中混合中子：伽马辐射暴露的描述恒河猴​​ DRR 的数据集的评论摘要，以作为对犬类数据集的比较参考。现有证据提供了一个可靠且广泛的数据库，该数据库描述了暴露于混合中子：相对于 250 kVp、1-2 MeV x 辐射和 Co 伽马的可变能量伽马辐射的犬科动物和年轻恒河猴的 H-ARS 的 DRR，以及没有医疗管理的好处的均匀和不均匀的全身照射。相对于两个物种内的参考辐射暴露，混合中子：伽马辐射显示出约 1.0 到 2.0 的能量依赖性 RBE。一个边缘数据库描述了胃肠道 (GI)-ARS 的 DRR。相对于混合中子：γ 以及暴露于参考辐射，医疗管理对这两个物种都显示出益处。H-ARS 的 DRR 以陡峭的斜率和相对 LD50/30 值为特征，反映了辐射质量、暴露方面、