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Expression and Prognostic Significance of the MMP Family Molecules in Bladder Cancer
Combinatorial Chemistry & High Throughput Screening ( IF 1.8 ) Pub Date : 2021-08-31 , DOI: 10.2174/1386207323666200917103253
Chong Shen 1 , La Da 1 , Zhouliang Wu 1 , Yujie Wang 1 , Shen Gao 1 , Dawei Tian 1 , Hailong Hu 1
Affiliation  

Background: Bladder cancer (BC) is the 10th most common cancer worldwide with significantly varied prognosis in different pathological subtypes. MMPs, a group of enzymes, could involve in the invasion and metastasis of numerous malignancies. The function of MMPs in BC is partly reported in several studies but with great conflicts; hence, a systematic analysis of expression levels and prognostic values of these MMP genes are still to be determined.

Methods: Firstly, differentially expressed genes (DEGs) of MMPs were identified in ONCOMINE, GEPIA, and UALCAN databases, and these DEGs were also detected by real-time RT-qPCR. More importantly, we investigated the clinical significance of these DEGs in BC patients via Kaplan- Meier (KM) Plotter, UALCAN, and cBioPortal databases.

Results: The study found that the mRNA expression of MMP1/11 in BC samples was significantly higher than that in normal bladder tissues, and MMP2/3 was lower in the former than in the latter. The expression level of MMP1/2/7/9/11/13/23B was significantly related to the tumor stages. Furthermore, the prognostic analysis suggested that the high transcription levels of MMP7 and low transcription levels of MMP23A were correlated with favorable relapse-free survival and overall survival in the patients with BC, respectively. Notably, high MMP11/13 expression levels indicated poor overall survival (OS) and relapse-free survival (RFS) in patients with BC.

Conclusion: This study revealed that MMP1/2/3/7/9/11/13/23A/23B are possible prognostic biomarkers and clinical therapeutic targets for patients with BC.



中文翻译:

MMP家族分子在膀胱癌中的表达及预后意义

背景:膀胱癌 (BC) 是全球第 10 位最常见的癌症,不同病理亚型的预后差异很大。MMPs是一组酶,可参与多种恶性肿瘤的侵袭和转移。MMPs在BC中的作用在几项研究中得到了部分报道,但存在很大的冲突;因此,这些 MMP 基因的表达水平和预后价值的系统分析仍有待确定。

方法:首先,在ONCOMINE、GEPIA和UALCAN数据库中鉴定出MMPs的差异表达基因(DEGs),并通过实时RT-qPCR检测这些差异表达基因(DEGs)。更重要的是,我们通过 Kaplan-Meier (KM) Plotter、UALCAN 和 cBioPortal 数据库研究了这些 DEG 在 BC 患者中的临床意义。

结果:研究发现,BC样本中MMP1/11的mRNA表达显着高于正常膀胱组织,且MMP2/3在前者低于后者。MMP1/2/7/9/11/13/23B的表达水平与肿瘤分期显着相关。此外,预后分析表明,MMP7 的高转录水平和 MMP23A 的低转录水平分别与 BC 患者良好的无复发生存期和总生存期相关。值得注意的是,高 MMP11/13 表达水平表明 BC 患者的总生存期 (OS) 和无复发生存期 (RFS) 较差。

结论:本研究表明,MMP1/2/3/7/9/11/13/23A/23B 可能是 BC 患者的预后生物标志物和临床治疗靶点。

更新日期:2021-06-29
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