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A Mathematical Model for Stem Cell Competition to Maintain a Cell Pool Injured by Radiation.
Radiation Research ( IF 3.4 ) Pub Date : 2020-09-16 , DOI: 10.1667/rade-20-00034.1
Kouki Uchinomiya 1 , Kazuo Yoshida 1 , Masahiro Kondo 2 , Masanori Tomita 1 , Toshiyasu Iwasaki 1
Affiliation  

The effect of low-dose-rate exposure to ionizing radiation on cancer risk is a major issue associated with radiation protection. Tissue stem cells are regarded as one of the targets of radiation-induced carcinogenesis. However, it is hypothesized that the effect of radiation may be reduced if damaged stem cells are eliminated via stem cell competition between damaged and intact stem cells. This would be particularly effective under very low-dose-rate conditions, in which only a few stem cells in a stem cell pool may be affected by radiation. Following this hypothesis, we constructed a simple mathematical model to discuss the influence of stem cell competition attenuating the accumulation of damaged cells under very low-dose-rate conditions. In this model, a constant number of cells were introduced into a cell pool, and the numbers of intact and damaged cells were calculated via transition and turnover events. A transition event emulates radiation dose, whereby an intact cell is changed into a damaged cell with a given probability. On the other hand, a turnover event expresses cell competition, where reproduction and elimination of cells occur depending on the properties of cells. Under very low-dose-rate conditions, this model showed that radiation damage to the stem cell pool was strongly suppressed when the damaged cells were less reproductive and tended to be eliminated compared to the intact cells. Furthermore, the size of the stem cell pool was positively correlated with reduction in radiation damage.



中文翻译:

干细胞竞争维持被辐射伤害的细胞池的数学模型。

低剂量率的电离辐射暴露对癌症风险的影响是与辐射防护相关的主要问题。组织干细胞被认为是辐射诱导的癌变的靶标之一。但是,假设如果通过受损和完整干细胞之间的干细胞竞争消除受损的干细胞,则辐射的作用可能会降低。这在非常低的剂量率条件下特别有效,在这种条件下,干细胞库中只有少数干细胞会受到辐射的影响。根据这个假设,我们构建了一个简单的数学模型来讨论干细胞竞争在非常低剂量率条件下减弱受损细胞积累的影响。在此模型中,将恒定数量的细胞引入细胞池,并通过过渡和周转事件计算完整和受损细胞的数量。过渡事件模拟辐射剂量,从而完整细胞以给定的概率变为受损细胞。另一方面,周转事件表示细胞竞争,其中取决于细胞的性质发生细胞的繁殖和消除。在非常低的剂量率条件下,该模型表明,与完整细胞相比,当受损细胞的生殖能力较弱并趋于消除时,对干细胞池的辐射损伤得到了强烈抑制。此外,干细胞库的大小与辐射损伤的减少呈正相关。从而完整的单元格以给定的概率变为损坏的单元格。另一方面,周转事件表示细胞竞争,其中取决于细胞的性质发生细胞的繁殖和消除。在非常低的剂量率条件下,该模型表明,与完整细胞相比,当受损细胞的生殖能力较弱并趋于消除时,对干细胞池的辐射损伤得到了强烈抑制。此外,干细胞库的大小与辐射损伤的减少呈正相关。从而完整的单元格以给定的概率变为损坏的单元格。另一方面,周转事件表示细胞竞争,其中取决于细胞的性质发生细胞的繁殖和消除。在非常低的剂量率条件下,该模型表明,与完整细胞相比,当受损细胞的生殖能力较弱并趋于消除时,对干细胞池的辐射损伤得到了强烈抑制。此外,干细胞库的大小与辐射损伤的减少呈正相关。该模型表明,与完整细胞相比,当受损细胞的生殖能力较弱并趋于消除时,对干细胞池的辐射损伤得到了强烈抑制。此外,干细胞库的大小与辐射损伤的减少呈正相关。该模型表明,与完整细胞相比,当受损细胞的生殖能力较弱并趋于消除时,对干细胞池的辐射损伤得到了强烈抑制。此外,干细胞库的大小与辐射损伤的减少呈正相关。

更新日期:2020-10-12
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