Self-assembled hierarchical nanostructures are slowly superseding their conventional counterparts for use in biosensors. These morphologies show high surface area with tunable porosity and packing density. Modulating the interfacial interactions and subsequent particle assembly occurring at the water-and-oil interface in inverse miniemulsions, are amongst the best strategies to stabilize various type of hollow nanostructures. The paper presents a successful protocol to obtain CeO2hollow structures based biosensors that are useful for glucose sensing. The fabricated glucose sensor is able to deliver high sensitivity (0.495 μA cm-2nM-1), low detection limit (6.46 nM) and wide linear range (0 nM to 600 nM). CeO2based bioelectrode can also be considered as a suitable candidate for protein sensors. It can detect protein concentrations varying from 0 to 30 µM, which is similar or higher than most reports in the literature. The limit of detection (LOD) for protein was ~ 0.04 µM. Therefore, the hollow CeO2electrodes, with excellent reproducibility, stability and repeatability, opens a new area of application for cage-frame type nanoparticles.

中文翻译：

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用于生物传感应用的 CeO2 分级笼框型纳米结构：从葡萄糖到蛋白质检测

自组装分层纳米结构正在慢慢取代其传统的对应物用于生物传感器。这些形态显示出具有可调孔隙率和堆积密度的高表面积。调节反相细乳液中发生在水-油界面的界面相互作用和随后的粒子组装，是稳定各种类型中空纳米结构的最佳策略之一。本文提出了一种成功的协议，以获得基于 CeO2 空心结构的生物传感器，该生物传感器可用于葡萄糖传感。制造的葡萄糖传感器能够提供高灵敏度 (0.495 μA cm-2nM-1)、低检测限 (6.46 nM) 和宽线性范围 (0 nM 至 600 nM)。基于 CeO2 的生物电极也可以被认为是蛋白质传感器的合适候选者。它可以检测从 0 到 30 µM 不等的蛋白质浓度，这与文献中的大多数报道相似或更高。蛋白质的检测限 (LOD) 约为 0.04 µM。因此，空心CeO2电极具有优异的重现性、稳定性和可重复性，为笼框型纳米粒子开辟了新的应用领域。