Cybergenetic systems use computer interfaces to enable feed-back controls over biological processes in real time. The complex and dynamic nature of cellular metabolism makes cybergenetics attractive for controlling engineered metabolic pathways in microbial fermentations. Cybergenetics would not only create new avenues of research into cellular metabolism, it would also enable unprecedented strategies for pathway optimization and bioreactor operation and automation. Implementation of metabolic cybergenetics, however, will require new capabilities from actuators, biosensors, and control algorithms. The recent application of optogenetics in metabolic engineering, the expanding role of genetically encoded biosensors in strain development, and continued progress in control algorithms for biological processes suggest that this technology will become available in the not so distant future.

中文翻译：

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光遗传学和生物传感器为代谢电子遗传学奠定了基础。

网络遗传系统使用计算机接口来实时反馈对生物过程的控制。细胞代谢的复杂性和动态性使计算机遗传学对于控制微生物发酵中的工程代谢途径具有吸引力。网络遗传学不仅会为细胞代谢创造新的研究途径，还将为通路优化以及生物反应器的操作和自动化提供前所未有的策略。然而，代谢电子遗传学的实施将需要执行器，生物传感器和控制算法的新功能。光遗传学在代谢工程中的最新应用，遗传编码生物传感器在菌株开发中的扩展作用，