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Regenerative Potential of a Suspension and Spheroids of Multipotent Mesenchymal Stromal Cells from Human Umbilical Cord on the Model of Myocardial Infarction in Rats
Bulletin of Experimental Biology and Medicine ( IF 0.7 ) Pub Date : 2020-08-01 , DOI: 10.1007/s10517-020-04928-0
M E Krasina 1 , N V Kosheleva 1, 2, 3 , T V Lipina 1 , M Yu Karganov 2 , Yu S Medvedeva 2 , M A Lebedeva 2 , I M Zurina 2, 3, 4 , I N Saburina 2, 3
Affiliation  

Regenerative potential of multipotent mesenchymal stromal cells from the human umbilical cord (MMSC-UC) in the suspension and spheroid form was revealed during the progression of experimental small focal myocardial infarction in rats. In isoproterenol-induced myocardial infarction, foci of necrosis and inflammatory infiltrate and at later terms fibrosis foci were found mainly in the left ventricle of rat heart. In rats receiving MMSC-UC, destructive changes in the myocardium, fibrous scars, and inflammatory process were less pronounced. MMSC-UC also contributed to normalization of the morphofunctional parameters of the heart. Spheroids exhibited higher efficiency in comparison with cell suspension.

中文翻译:

人脐带多能间充质基质细胞悬浮液和球体对大鼠心肌梗死模型的再生潜力

在大鼠实验性小灶性心肌梗死的进展过程中,揭示了悬浮和球体形式的人脐带多能间充质基质细胞 (MMSC-UC) 的再生潜力。在异丙肾上腺素诱导的心肌梗塞中,坏死和炎症浸润灶以及后来的纤维化灶主要在大鼠心脏的左心室中发现。在接受 MMSC-UC 的大鼠中,心肌、纤维疤痕和炎症过程的破坏性变化不太明显。MMSC-UC 还有助于心脏形态功能参数的正常化。与细胞悬液相比,球体表现出更高的效率。
更新日期:2020-08-01
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