PURPOSE To evaluate the effect of breast MRI on overall survival (OS) and disease-free survival (DFS) of patients with invasive breast cancer in the Netherlands. METHODS We selected all women from the Netherlands Cancer Registry diagnosed with invasive breast cancer (a) between 2011 and 2013 for the OS-cohort and (b) in the first quarter of 2012 for the DFS-cohort. The study population was subdivided into an MRI and non-MRI group. In addition, subgroups were created according to breast cancer subtype: invasive carcinoma of no special type (NST) versus invasive lobular carcinoma (ILC). OS and DFS were compared between the MRI and non-MRI group using the Kaplan-Meier method and the log-rank test. Cox proportional hazard regression analysis was performed to estimate hazard ratios (HR) with a 95% confidence interval (CI). To account for missing data, multiple imputation was performed. RESULTS Of the 31,756 patients included in the OS-cohort (70% non-MRI and 30% MRI), 27,752 (87%) were diagnosed with invasive carcinoma NST and 4004 (13%) with ILC. Of the 2464 patients included in the DFS-cohort (72% non-MRI and 28% MRI), 2161 (88%) were diagnosed with invasive carcinoma NST and 303 (12%) with ILC. The distribution of breast MRI use was significantly lower over different age categories, from 49.0% aged < 50 to 16.5% aged > 70. Multivariable Cox regression showed that breast MRI was not significantly associated with OS overall (HR 0.91, 95%-CI 0.74-1.11, p = 0.35), nor in the different histological subtypes. Multivariable Cox regression analysis showed that breast MRI was also not significantly associated with DFS (HR 1.16, 95%-CI 0.81-1.67), nor in the different histological subtypes. CONCLUSION Use of breast MRI was not significantly associated with an improved OS or DFS in patients treated with primary surgery.

中文翻译：

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乳腺 MRI 对乳腺癌患者无病生存率和总体生存率的影响：一项基于人群的回顾性研究。

目的 评估乳腺 MRI 对荷兰浸润性乳腺癌患者总生存期 (OS) 和无病生存期 (DFS) 的影响。方法 我们从荷兰癌症登记处选择了所有被诊断患有浸润性乳腺癌的女性 (a) 2011 年至 2013 年间的 OS 队列和 (b) 2012 年第一季度的 DFS 队列。研究人群被细分为 MRI 和非 MRI 组。此外，根据乳腺癌亚型创建了亚组：非特殊类型浸润性癌 (NST) 与浸润性小叶癌 (ILC)。使用 Kaplan-Meier 方法和对数秩检验比较 MRI 和非 MRI 组的 OS 和 DFS。进行 Cox 比例风险回归分析以估计具有 95% 置信区间 (CI) 的风险比 (HR)。为了解释缺失的数据，进行了多重插补。结果 在 OS 队列中包括的 31,756 名患者（70% 非 MRI 和 30% MRI）中，27,752 (87%) 名被诊断为浸润性癌 NST，4004 (13%) 名被诊断为 ILC。在 DFS 队列中包括的 2464 名患者（72% 非 MRI 和 28% MRI）中，2161 名（88%）被诊断为浸润性癌 NST，303 名（12%）被诊断为 ILC。乳腺 MRI 使用的分布在不同年龄组中显着较低，从 49.0% < 50 岁到 16.5% 岁 > 70 岁。多变量 Cox 回归显示乳腺 MRI 与总体 OS 无显着相关性（HR 0.91，95%-CI 0.74 -1.11, p = 0.35)，也不在不同的组织学亚型中。多变量 Cox 回归分析显示，乳腺 MRI 与 DFS 也没有显着相关性（HR 1.16，95%-CI 0.81-1.67），在不同的组织学亚型中也没有显着相关性。