A time-dependent postextraction differential acceleration (PEDA) potential was used to temporally focus increasingly heavy ions in a stigmatic imaging mass spectrometer, allowing them to be imaged with high mass and spatial resolutions over a broad mass-to-charge (m/z) range. By applying a linearly rising potential to the ion extraction electrode, sequential m/z ratios were subjected to a changing electric field, allowing their foci to coincide at the detector. Using this approach, at least 75% of the maximum mass resolution was obtained over a 300-600 Da range when the ion microscope was focused around 450 Da, representing more than a 10-fold increase over the conventional single-field PEDA method.

中文翻译：

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使用电动后萃取微分加速度在宽质量范围内进行高分辨率离子显微镜成像。

依赖时间的提取后微分加速（PEDA）电位用于在散光成像质谱仪中暂时聚焦越来越重的离子，从而使其能够在较宽的质荷比（m / z）上以高质量和空间分辨率成像。范围。通过将线性上升的电势施加到离子提取电极上，连续的m / z比将受到变化的电场的影响，从而使其焦点在检测器处重合。使用这种方法，当离子显微镜聚焦在450 Da左右时，在300-600 Da范围内获得了至少75％的最大质量分辨率，这比传统的单场PEDA方法增加了10倍以上。