Objective. Cochleae of long-term cochlear implant users have shown evidence of particulate platinum (Pt) corroded from the surface of Pt electrodes. The pathophysiological effect of Pt within the cochlea has not been extensively investigated. We previously evaluated the effects of Pt corrosion at high charge densities and reported negligible pathophysiological impact. The present study extends this work by examining techniques that may reduce Pt corrosion. Approach. Deafened guinea pigs were continuously stimulated for 28 d using biphasic current pulses at extreme charge densities using: (i) electrode shorting; (ii) electrode shorting with capacitive coupling (CC); or (iii) electrode shorting with alternating leading phase (AP). On completion of stimulation, cochleae were examined for corrosion product, tissue response, auditory nerve (AN) survival and trace levels of Pt; and electrodes examined for surface corrosion. Main results. Pt corrosion was evident ...

中文翻译：

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高电荷密度下的慢性耳蜗内电刺激：减少铂溶解。

客观的。长期人工耳蜗使用者的耳蜗已经显示出铂电极表面腐蚀颗粒铂 (Pt) 的证据。Pt 在耳蜗内的病理生理作用尚未得到广泛研究。我们之前评估了 Pt 腐蚀在高电荷密度下的影响，并报告了可以忽略不计的病理生理影响。本研究通过检查可以减少 Pt 腐蚀的技术来扩展这项工作。方法。使用双相电流脉冲在极端电荷密度下连续刺激耳聋豚鼠 28 天，方法如下：(i) 电极短路；(ii) 带有电容耦合 (CC) 的电极短路；或 (iii) 交替超前相位 (AP) 的电极短路。刺激完成后，检查耳蜗的腐蚀产物、组织反应、听神经 (AN) 存活率和痕量 Pt；和电极检查表面腐蚀。主要结果。铂腐蚀很明显...