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A rheostat sets B-cell receptor repertoire selection to distinguish self from non-self.
Current Opinion in Immunology ( IF 7 ) Pub Date : 2020-09-08 , DOI: 10.1016/j.coi.2020.07.003
Peter K Jani 1 , Hiromi Kubagawa 1 , Fritz Melchers 1
Affiliation  

In bone marrow VDJ-recombination continuously generates original repertoires of immature B cells expressing IgM-B cell receptor (BcR), in which each cell recognizes the wide variety of self and non-self antigens with an individually different spectrum of avidities. High avidity self-reactive B cells try to edit their BcRs by secondary or multiple VL-rearrangements to JL-rearrangements. If they do not manage to change their self reactivity, they are deleted by apoptosis. Low avidity self-reactive B cells are anergized, while B cells with no avidity to self are ignored. A rheostat crosslinking antigen-binding BcRs, self antigen complexed with pentameric IgM and Fcμ-receptor monitors high, low or no binding. PI3K and PTEN are the effectors of this self antigen-sensing device. In mature B cells this rheostat continues to function in the activation of resting B cells by foreign antigens which crosslink BcR, antigen and pentameric IgM with Fcμ-receptors.

中文翻译:

变阻器设置 B 细胞受体库选择以区分自我和非自我。

在骨髓中,VDJ 重组不断产生表达 IgM-B 细胞受体 (BcR) 的未成熟 B 细胞的原始库,其中每个细胞都能识别各种具有不同亲合力谱的自身和非自身抗原。高亲合力自反应 B 细胞试图通过二次或多次 VL 重排到 JL 重排来编辑它们的 BcR。如果它们没有设法改变它们的自身反应性,它们就会被细胞凋亡删除。低亲和力的自反应 B 细胞被激活,而对自身没有亲和力的 B 细胞被忽略。变阻器交联抗原结合 BcR,自身抗原与五聚体 IgM 和 Fcμ 受体复合,可监测高、低或无结合。PI3K 和 PTEN 是这种自抗原感应装置的效应器。
更新日期:2020-09-08
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