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SenseBack - An Implantable System for Bidirectional Neural Interfacing.
IEEE Transactions on Biomedical Circuits and Systems ( IF 5.1 ) Pub Date : 2020-09-10 , DOI: 10.1109/tbcas.2020.3022839
Ian Williams , Emma Brunton , Adrien Rapeaux , Yan Liu , Song Luan , Kianoush Nazarpour , Timothy Constandinou

Chronic in-vivo neurophysiology experiments require highly miniaturized, remotely powered multi-channel neural interfaces which are currently lacking in power or flexibility post implantation. In this article, to resolve this problem we present the SenseBack system, a post-implantation reprogrammable wireless 32-channel bidirectional neural interfacing that can enable chronic peripheral electrophysiology experiments in freely behaving small animals. The large number of channels for a peripheral neural interface, coupled with fully implantable hardware and complete software flexibility enable complex in-vivo studies where the system can adapt to evolving study needs as they arise. In complementary ex-vivo and in-vivo preparations, we demonstrate that this system can record neural signals and perform high-voltage, bipolar stimulation on any channel. In addition, we demonstrate transcutaneous power delivery and Bluetooth 5 data communication with a PC. The SenseBack system is capable of stimulation on any channel with ±20 V of compliance and up to 315 μA of current, and highly configurable recording with per-channel adjustable gain and filtering with 8 sets of 10-bit ADCs to sample data at 20 kHz for each channel. To the best of our knowledge this is the first such implantable research platform offering this level of performance and flexibility post-implantation (including complete reprogramming even after encapsulation) for small animal electrophysiology. Here we present initial acute trials, demonstrations and progress towards a system that we expect to enable a wide range of electrophysiology experiments in freely behaving animals.

中文翻译:

SenseBack - 用于双向神经接口的可植入系统。

慢性的体内神经生理学实验需要高度小型化、远程供电的多通道神经接口,这些神经接口目前在植入后缺乏动力或灵活性。在本文中,为了解决这个问题,我们介绍了 SenseBack 系统,这是一种植入后可重新编程的无线 32 通道双向神经接口,可以在自由行为的小动物中进行慢性外周电生理学实验。用于外围神经接口的大量通道,加上完全可植入的硬件和完整的软件灵活性,可实现复杂的体内系统可以适应不断变化的学习需求的研究。在互补离体体内准备工作,我们证明该系统可以记录神经信号并在任何通道上执行高压双极刺激。此外,我们还演示了经皮供电和与 PC 的蓝牙 5 数据通信。SenseBack 系统能够以 ±20 V 的顺从性和高达 315 μA 的电流在任何通道上进行刺激,并且具有高度可配置的记录,每通道可调节增益和过滤,使用 8 组 10 位 ADC 以 20 kHz 采样数据对于每个频道。据我们所知,这是第一个为小动物电生理学提供这种水平的植入后性能和灵活性(包括甚至在封装后完全重新编程)的植入式研​​究平台。在这里,我们提出初步的急性试验,
更新日期:2020-10-16
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