Background: Despite the high incidence of muscle weakness in patients with amyotrophic lateral sclerosis (ALS), the effects of therapeutic exercise on these individuals have not been clearly determined. Methods: A comprehensive database search was conducted on PubMed, Embase, Cochrane Library, and SCOPUS. We included studies published up to December 31, 2019 that fulfilled our inclusion and exclusion criteria. Functional status was determined as the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) score (previous and revised versions) before and after a therapeutic exercise program for the meta-analysis. The Cochrane Collaboration's tool for assessing risk of bias in randomized trials was used for the methodological quality assessments of included studies. The meta-analysis was performed using the RevMan v.5.3. Results: A total of 94 patients in the experimental group (who received therapeutic exercise) and 159 patients in the control group (who received conventional exercise or therapy) were included from five randomized controlled trials. The decrement of ALSFRS (previous version), ALSFRS-R (revised version), and ALSFRS-R-Respiratory scores at the 6-month evaluation were less for the therapeutic exercise group as compared to the control group. However, at the 6-month evaluation, the ALSFRS-R-Limb scores did not significantly differ between the two groups. Conclusions: Therapeutic exercise appears beneficial for patients with ALS. Further, it appears to exert more of a cardiopulmonary benefit, as opposed to preventing the progression of limb weakness. However, as the therapeutic exercises applied in each included study were not uniform, the result of our meta-analysis should be considered cautiously.

中文翻译：

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治疗性运动可以减缓肌萎缩性侧索硬化患者的进行性功能衰退吗？荟萃分析。

背景：尽管在肌萎缩性侧索硬化症（ALS）患者中肌肉无力的发生率很高，但尚不清楚治疗性锻炼对这些个体的影响。方法：在PubMed，Embase，Cochrane Library和SCOPUS上进行了全面的数据库搜索。我们纳入了截至2019年12月31日发表的符合我们纳入和排除标准的研究。在进行荟萃分析的治疗性锻炼计划之前和之后，将功能状态确定为肌萎缩性侧索硬化功能评定量表（ALSFRS）评分（以前和修订的版本）。Cochrane协作的评估随机试验中偏倚风险的工具被用于纳入研究的方法学质量评估。使用RevMan v.5.3进行荟萃分析。结果：五个随机对照试验共纳入了实验组的94名患者（接受治疗性运动）和对照组的159名患者（接受了常规运动或治疗）。与对照组相比，治疗性运动组在6个月评估时的ALSFRS（先前版本），ALSFRS-R（修订版）和ALSFRS-R-呼吸评分的降低幅度较小。但是，在6个月的评估中，两组之间的ALSFRS-R-Limb得分没有显着差异。结论：治疗性运动似乎对ALS患者有益。此外，与预防肢体无力的发展相反，它似乎具有更多的心肺功能。但是，由于在每个纳入的研究中应用的治疗方法都不统一，