Eukaryotic initiation factor 2 (eIF2) plays a fundamental role in the regulation of protein synthesis. Investigations have revealed that the regulation of eIF2 is robust against intrinsic uncertainties and is able to efficiently counteract them. The robustness properties of the eIF2 pathway against intrinsic disturbances is also well known. However the reasons for this ability to counteract stresses is less well understood. In this article, the robustness conferring properties of the eIF2 dependent regulatory system is explored with the help of a mathematical model. The novelty of the work presented in this article lies in articulating the possible reason behind the inbuilt robustness of the highly engineered eIF2 system against intrinsic perturbations. Our investigations reveal that the robust nature of the eIF2 pathway may originate from the existence of an attractive natural sliding surface within the system satisfying reaching and sliding conditions that are well established in the domain of control engineering.

中文翻译：

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eIF2 监管系统抵消不确定性的内在趋势。

真核起始因子 2 (eIF2) 在蛋白质合成的调节中起重要作用。调查表明，eIF2 的调节对于内在的不确定性是稳健的，并且能够有效地抵消它们。eIF2 通路对内在干扰的鲁棒性也是众所周知的。然而，人们对这种抗压能力的原因了解得较少。在本文中，借助数学模型探讨了 eIF2 依赖性调节系统的稳健性赋予特性。本文中介绍的工作的新颖之处在于阐明了高度工程化的 eIF2 系统对内在扰动的内在稳健性背后的可能原因。