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Investigation of Plasmonic Detection of Human Respiratory Virus.
Advanced Theory and Simulations ( IF 3.3 ) Pub Date : 2020-06-08 , DOI: 10.1002/adts.202000074
Chandreyee Manas Das 1, 2 , Yan Guo 3 , Lixing Kang 1, 2 , Ho-Pui Ho 4 , Ken-Tye Yong 1, 2
Affiliation  

The COVID-19 virus has been recently identified as a new species of virus that can cause severe infections such as pneumonia. The sudden outbreak of this disease is being considered a pandemic. Given all this, it is essential to develop smart biosensors that can detect pathogens with minimum time delay. Surface plasmon resonance (SPR) biosensors make use of refractive index (RI) changes as the sensing parameter. In this work, based on actual data taken from previous experimental works done on plasmonic detection of viruses, a detailed simulation of the SPR scheme that can be used to detect the COVID-19 virus is performed and the results are extrapolated from earlier schemes to predict some outcomes of this SPR model. The results indicate that the conventional Kretschmann configuration can have a limit of detection (LOD) of 2E-05 in terms of RI change and an average sensitivity of 122.4 degRIU-1 at a wavelength of 780 nm.

中文翻译:

人类呼吸道病毒等离子检测的研究。

COVID-19 病毒最近被确定为一种新型病毒,可​​引起肺炎等严重感染。这种疾病的突然爆发被认为是大流行病。鉴于这一切,必须开发能够以最小时间延迟检测病原体的智能生物传感器。表面等离子共振 (SPR) 生物传感器利用折射率 (RI) 变化作为传感参数。在这项工作中,基于从先前对病毒等离子检测所做的实验工作中获取的实际数据,对可用于检测 COVID-19 病毒的 SPR 方案进行了详细模拟,并从早期方案中推断出结果来预测这个 SPR 模型的一些结果。
更新日期:2020-06-08
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